Identification of the susceptive genes for atopic diseases using positional candidate gene approaches.

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Childhood-onset asthma is frequently found in association with atopy. We conducted a genomewide linkage search in 47 Japanese families (197 members) with more than two mite-sensitive atopic asthmatics (65 affected sib-pairs) using 398 markers. Multipoint linkage analysis was carried out for atopic asthma as a quantitative trait using the MAPMAKER/SIB program. We observed significant evidence for linkage with maximum lod scores (MLS) of 4.8 on 5q31-q33. In addition, suggestive evidence on 4q35 with MLS=2.7 and on 13q11 with MLS=2.4 was obtained. The other possible linkage regions included 6p22-p21.3 (MLS=2.1), 12q21-q23 (MLS=1.9), and 13q14.1-q14.3 (MLS=2.0). Furthermore, we observed suggestive evidence for linkage with atopic dermatitis on 5q31-q33 and 12q21-q23. These data suggest that the chromosome region of 5q31-q33 and 12q21-q23 may be common susceptive region of atopic asthma and atopic dermatitis.