Investigation of Filaggrin Gene Mutations among Latinx patients with Atopic Dermatitis

拉丁裔特应性皮炎患者丝聚蛋白基因突变的调查

基本信息

项目摘要

Research: of givers complex FLG persistent aside of represents sociocultural as mutations risk development Candidate: Rico became Clinical currently funded focus time Chiesa dermatologist will Dr. with relationship, Biostatistics, Genetics benefit Resource-based Center (SBDRC) at Penn. Career focus completion knowledge become Atopic dermatitis (AD) is a chronic, inflammatory disease characterized by episodes acute disease flares, resulting in significant morbidity and disease burden to patients, care and health systems. While the etiology of AD remains unknown, it is thought to involve a interplay between genetic, immune, and environmental mechanisms. Mutations in the gene result in skin barrier dysfunction and are associated with more severe and disease in AD. However, little is known about the genetics of AD in other populations from those o European ancestry. Latinx are an admixed population and have higher rates AD compared to non-Latinx whites. The study of admixed populations such as Latinx an opportunity to examine the individual contributions of ancestry, genetics, and the interactions with genetic variation to the pathogenesis of complex diseases such AD. The main purpose of this study is to examine the presence of FLG loss of function (LoF) and (2) to explore the relationship between ancestry, genetic variation, and disease in Latinx with AD. Data obtained from this study, would then serve to inform the of future research to help us improve our diagnostic and management strategies. Zelma C. Chiesa Fuxench, M.D., M.S.C.E. graduated from the University of Puerto School of Medicine (2008). She completed her residency training at said institution and board-certified in dermatology (2013). Dr. Chiesa completed her Master of Science i n Epidemiology (MSCE) in 2016 at the University of Pennsylvania (Penn) where she is an Assistant Professor of Dermatology. Dr. Chiesa's current goal i s to become a R01 independent investigator focused on the epidemiology and genetics of AD with a specific on Latinx. Environment: During the time of this award, Dr. Chiesa will devote 20% of her to caring for patients with AD and 80% to clinical research work. Dr. Margolis and Dr. currently have a long-standing mentor-mentee relationship. He is a well-renowned and dermatoepidemiologist, and an expert in the genetic epidemiology of AD and serve as Dr. Chiesa's primary mentor. Dr. Chiesa will also benefit from the mentorships of oel M. Gelfand M.D. M.S.C.E., a renowned expert in the field of dermatoepidemiology and whom Dr. Chiesa has collaborated extensively as part of an established mentor-mentee Dr. Nandita Mitra, Ph.D., (Professor of Biostatistics at the Department of Epidemiology and Informatics at PSOM) and Dr. Sarah Tishkoff (Professor of Penn Center for Global Genomics and Health Equity at Penn). Dr. Chiesa will also from the rich training environment at Penn including the Development: Dr. Chiesa will primarily her training on genetic epidemiology and use of statistical methods in genetics. With of the proposed research and career development plan, Dr. Chiesa will acquire the and skills necessary to achieve a strong foundation to an independent, patient-oriented clinical researcher. f J Skin Biology and Diseases
研究:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Zelma Charlotte Chiesa Fuxench其他文献

Zelma Charlotte Chiesa Fuxench的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
  • 批准号:
    10065645
  • 财政年份:
    2023
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 17.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了