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Ultra high field MRI for small animals

小动物超高场 MRI

基本信息

批准号：
456565718
负责人：
金额：
--
依托单位：
Friedrich-Alexander-Universität Erlangen-Nürnberg
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2021
资助国家：
德国
起止时间：
2020-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/456565718?language=en
关键词：
Ultra field MRI small animals

项目摘要

Non-invasive imaging in small animals using magnetic resonance imaging is an indispensable part of preclinical research and enables the non-invasive detection of morphological, functional and molecular organ and tissue changes. The research projects mentioned in this application focuses on oncologic and immunologic topics for imaging in mouse and rat models, using the development of novel and innovative imaging methods to improve the diagnosis of oncologic and immunologic diseases. Small animal imaging is performed in the already established laboratory for experimental multimodal imaging (Preclinical Imaging Platform Erlangen) in close cooperation with renowned experts in magnetic resonance physics. In the Preclinical Imaging Platform Erlangen we have access to further dedicated small animal scanners whose imaging information can be considered as complementary to magnetic resonance imaging: Computed tomography, positron emission tomography, optical imaging and ultrasound. In terms of multimodal imaging, the magnetic resonance scanner will be integrated into the central small animal imaging unit of the Friedrich-Alexander University in order to correlate results with other modalities. Since the equipment applied for is a replacement of a currently existing ultra-high field magnetic resonance tomograph that is no longer supported by the manufacturer, the entire infrastructure is already in place and can be used without any changes. The laboratories of the Preclinical Imaging Platform Erlangen are attached to the central animal facility of the Friedrich-Alexander University and are fully integrated in terms of hygiene. Since the Preclinical Imaging Platform Erlangen is operated as a core facility, the magnetic resonance tomograph applied for is also available to other preclinically oriented research groups of the university.

利用磁共振成像对小动物进行无创成像是临床前研究不可缺少的一部分，可以无创地检测形态学、功能和分子器官和组织的变化。本申请中提到的研究项目集中于肿瘤和免疫主题的小鼠和大鼠模型成像，利用新的和创新的成像方法的发展，以提高肿瘤和免疫疾病的诊断。小动物成像在已经建立的实验多模态成像实验室（临床前成像平台Erlangen）进行，与著名的磁共振物理专家密切合作。在临床前成像平台Erlangen，我们有更多的专用小动物扫描仪，其成像信息可以被认为是磁共振成像的补充：计算机断层扫描，正电子发射断层扫描，光学成像和超声。在多模态成像方面，磁共振扫描仪将集成到弗里德里希-亚历山大大学的中央小动物成像单元中，以便将结果与其他模态相关联。由于所申请的设备是替换现有的制造商不再支持的超高场磁共振层析仪，因此整个基础设施已经到位，无需任何更改即可使用。临床前成像平台Erlangen的实验室附属于弗里德里希-亚历山大大学的中央动物设施，并在卫生方面完全整合。由于Erlangen临床前成像平台是核心设施，因此申请的磁共振断层成像也可供学校其他临床前研究小组使用。