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Optical Tomography Using Echo Pulses Modulated by Light for Medical Diagnosis

使用光调制的回波脉冲进行医学诊断的光学断层扫描

基本信息

批准号：
14350222
负责人：
HORINAKA Hiromichi
金额：
$ 6.85万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14350222/
关键词：
optical tomography tissue near infrared light ultrasonic velocity medical diagnosis light scattering ultrasonic pulse cancer

项目摘要

A new imaging method using the interaction between the near infrared light and the ultrasonic wave was investigated for application to medical diagnosis.A measuring equipment of the method using the ultrasonic transducer of 5 MHz resonant frequency was fabricated for construction of optical tomography. The method was applied to a biological tissue (a dog stomach) including absorbing objects. Ultrasonic echo pulses from the back boundaries of absorption region showed the time shift when the laser diode illuminated the sample. The image reconstructed from the velocity change revealed the shape of the absorption area in the dog stomach. Experimental results show that this method has the possibility for application to diagnosis of the spatial distribution of malignant tumor.Our equipment for optical tomography was insufficient for tissue characterization. An ultrasonic transducer of 20 MHz resonant frequency was employed instead of the transducer of 5MHz for improvement of spatial resolution. The ultrasonic echo pulse shift which was caused by the elastic coefficient change of the medium was detected under the light illumination of intensity within the skin exposure limit. Narrow boundaries of colored agar under chicken meat were observed in the image constructed from ultrasonic velocity change. The measuring equipment with improved spatial resolution is expected to apply to measurement of distribution of oxy-hemoglobin at the specified distance from the skin and spatial diagnosis of tumors.The high power laser diode was attached to the commercial ultrasonic diagnostic equipment. The array transducer of the equipment was employed to detect the ultrasonic velocity shift due to light illumination in the sample. Images of the sample were constructed from waveforms of the array transducer. The detail image of the absorption distribution in the sample was obtained.

研究了一种利用近红外光与超声波相互作用进行医学成像的新方法，并研制了一台用于光学层析成像的测量装置，该装置采用谐振频率为5 MHz的超声换能器。将该方法应用于包括吸收物体的生物组织（狗胃）。当激光二极管照射样品时，来自吸收区后边界的超声回波脉冲显示出时间偏移。从速度变化重建的图像揭示了狗胃中吸收区的形状。实验结果表明，该方法具有应用于诊断恶性肿瘤的空间分布的可能性。为了提高空间分辨率，采用了20 MHz的超声换能器代替了5 MHz的换能器。在皮肤暴露极限强度的光照下，检测到由于介质弹性系数变化引起的超声回波脉冲偏移。在超声速度变化图像中，观察到鸡肉下彩色琼脂的窄边界。该测量设备具有更高的空间分辨率，有望应用于离皮肤特定距离处氧合血红蛋白分布的测量和肿瘤的空间诊断。该设备的阵列换能器用于检测样品中由于光照射引起的超声速度偏移。从阵列换能器的波形构建样品的图像。获得了样品中吸收分布的详细图像。