Near Infrared Light Activated Adhesives for Nerve Repair

用于神经修复的近红外光激活粘合剂

基本信息

  • 批准号:
    10436799
  • 负责人:
  • 金额:
    $ 19.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-23 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

SUMMARY Nerve damage from trauma including combat, accidents, sports injuries, and neuropathies, affects over 350,000 patients annually in the U.S. resulting in loss of sensation, chronic pain, and sometimes permanent disability. Surgery is generally required for in case of peripheral nerve injury because of the slow rate of repair and regeneration. Nerve repair generally involves direct approximation of the severed nerves for small gaps and placement of allografts of synthetic grafts to facilitate nerve regeneration for large nerve gaps. Suturing is the clinical standard for nerve repair and involves apposition of the outermost layer or epineurium under a surgical microscope. Epineural suturing is time consuming, requires significant skill, and can result in chronic inflammation, fibrosis, and asymmetrical tension. Existing glues typically do not provide significant added benefit and suffer from weaker mechanical properties and complexities in application. Reduction in procedure times, generation of minimal-tension approximation, and prevention of scar formation are critical for improving repair outcomes and costs in peripheral nerve injuries. In this research, we will develop novel formulations of near infrared light activable adhesives (NILAAs) for rapid epineural sealing and subsequent nerve repair. A set of NILAA biomaterials will be generated and characterized for their rheological and mechanical properties. The response of NILAA biomaterials to different wavelengths and power intensities of near infrared light will be determined and optimal sealing conditions will be identified using a mathematical model in concert with thermal imaging. NILAAs that demonstrate effective ex vivo sealing will be used to determine efficacy of nerve repair in a sciatic injury model in rats. NILAAs will be used as glues to seal small gaps i.e. transverse incision and as tapes or wraps to secure synthetic regenerative conduits in large (1 cm) defects in the sciatic nerve in Sprague Dawley rats. Muscle electromyographic (EMG) response, biomechanical recovery, and cellular and biochemical responses will be determined for nerves sealed and repaired using NILAAs, and their performance will be compared to sutures and glues. A combination approach of sutures with NILAAs will also be investigated for facilitating nerve repair. We propose that NILAAs are innovative approach for epineural sealing, repair and regeneration of small as well as large nerve defects leading to faster operation times and better quality of repair including low trauma, scarring, and inflammation, which make this technology highly attractive for clinical translation.
总结

项目成果

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Kaushal Rege其他文献

Kaushal Rege的其他文献

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{{ truncateString('Kaushal Rege', 18)}}的其他基金

Laser-Activated Nanoglues for the prevention and control of surgical site infections
激光激活纳米胶用于预防和控制手术部位感染
  • 批准号:
    10249234
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10457977
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
DEVELOPMENT OF NOVEL AMINOGLYCOSIDE POLYMERS AND NANOPARTICLES FOR NUCLEIC ACID DELIVERY IN CHRONIC WOUNDS
开发用于慢性伤口核酸输送的新型氨基糖苷聚合物和纳米颗粒
  • 批准号:
    10009545
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10226324
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10676763
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10053067
  • 财政年份:
    2020
  • 资助金额:
    $ 19.72万
  • 项目类别:
Photothermal Nanocomposites for Tissue Repair
用于组织修复的光热纳米复合材料
  • 批准号:
    8945323
  • 财政年份:
    2015
  • 资助金额:
    $ 19.72万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8602837
  • 财政年份:
    2011
  • 资助金额:
    $ 19.72万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8212217
  • 财政年份:
    2011
  • 资助金额:
    $ 19.72万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8416396
  • 财政年份:
    2011
  • 资助金额:
    $ 19.72万
  • 项目类别:

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