Functional polymer nanospheres prepared with reactive and biodegradable polymer surfactant

活性可生物降解聚合物表面活性剂制备的功能聚合物纳米球

• 批准号: 14350411
• 负责人: YOSHIZAWA Hidekazu
• 金额: $ 9.34万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14350411/
• 关键词: Polymer surfactant; Polymer nanospheres; Macromer; Surfmer; Polyaspartate; Emulsion polymerization; Dispersion polymerization; Polymer Colloid; 高分子ナノスフェア; 高分子コロイド; 高分子マクロマー; 高分子ミクロスフェア; 反応性分散剤

The paramount objective of this research is to synthesize a reactive and biodegradable polymer surfactant and to establish the technique applicable to the control of surface properties of polymer nanospheres prepared by heterogeneous polymerization with the synthesized surfactant. The following results were obtained.l. We successfully synthesized the reactive and biodegradable polymer surfactant of polyaspartate partially bearing vinyl benzyl moiety which had a potential of radical polymerization.2. Emulsion copolymerization with styrene using the synthesized polymer surfactant provided stably-dispersed polymer nanospheres with a diameter of 200〜400 nm. The diameter was found to be controllable by changing a recipe in polymerization.3. Polymer nanospheres prepared by emulsion copolymerization was covered with polyaspartate derivative from a view point of ζ-potential measurement which was -40 mV. It was considered that this high z-potential was contributed to carboxyl group of polyaspartate macromer.4. Dispersion, copolymerization with styrene using the synthesized polyaspartate macromer as a reactive dispersant gave smaller polymer nanospheres by emulsion copolymerization. The diameter of the prepared polymer nanospheres was controlled between 35〜150 nm.5. The concentration of polyaspartate macromer, the introduction degree of vinyl benzyl moiety and the molecular weight of main chain were found to be significant parameters affected diameter of the prepared polymer nanospheres.6. As the synthesized polyaspartate macromonomer formed intermolecular association, homopolymerization of polyaspartate macromer was conducted to prepare much smaller nanospheres. The result was suggested the formation of polymer nanospheres with a diameter of 10〜30 nm.7. By heterogeneous copolymerzation of styrene with the reactive and biodegradable polymer surfactant derived from polyaspartate, we can successfully control a diameter of polymer nanospheres with a range between 10〜400 nm.

本研究的首要目标是合成一种反应性且可生物降解的聚合物表面活性剂，并建立适用于控制由合成表面活性剂非均相聚合制备的聚合物纳米球表面性质的技术。得到以下结果。成功合成了具有自由基聚合潜力的部分带有乙烯基苄基的聚天冬氨酸酯反应型可生物降解高分子表面活性剂。 2．使用合成的聚合物表面活性剂与苯乙烯进行乳液共聚，得到稳定分散的直径为200〜400 nm的聚合物纳米球。发现通过改变聚合配方可以控制直径。 3．通过乳液共聚合制备的聚合物纳米球被聚天冬氨酸衍生物覆盖，从测量的 z 电位来看，其为-40 mV。据认为这种高z电位是由聚天冬氨酸大分子单体的羧基造成的。4．使用合成的聚天冬氨酸大分子单体作为反应性分散剂与苯乙烯进行分散、共聚，通过乳液共聚得到更小的聚合物纳米球。制备的聚合物纳米球的直径控制在35〜150 nm之间。 5．发现聚天冬氨酸大分子单体的浓度、乙烯基苄基部分的引入程度和主链分子量是影响所制备的聚合物纳米球直径的重要参数。 6．由于合成的聚天冬氨酸大分子单体形成分子间缔合，因此进行聚天冬氨酸大分子单体的均聚以制备更小的纳米球。结果表明形成了直径为10～30 nm的聚合物纳米球。7．通过苯乙烯与聚天冬氨酸衍生的反应性可生物降解聚合物表面活性剂的非均相共聚，我们可以成功地将聚合物纳米球的直径控制在10〜400 nm范围内。