Sudden death during bating: cardiovascular collapse by experimental hyperthermia

击球时突然死亡：实验性高热导致心血管崩溃

• 批准号: 14370146
• 负责人: HORI Shingo
• 金额: $ 6.02万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370146/
• 关键词: hyperthermia; water immersion; cytokine; bathing; shock; heat stroke; rat; 熱中症; 循環不全

A new model for hyperthermia in rat model is produced and challenged simulating the hot bath immersion inducing sudden death in Japan. Above 40 degree C, rats are found to be vulnerable for shock and death. The homodynamic study showed that exaggerated hypertension, tachycardia and tachypnea are initial events which then progressed to shock and cardiac arrest. Although the sequence has already been reported in heat stroke model of rats using air-chamber of 42 to 43 degree C, liquid as heat transfer media is better to confer heat energy sooner than air, indicating this model may serve as an unique model useful for considering the risk of hot bath water immersion responsible more than 14,000 deaths annually in Japan. The threshold value for death of water temperature is more than 40 degree C, of body temperature is 42 degree C. On cessation of heating, rats with body temperature more than 43 degree C showed shock and eventually died, although those less than 42 degree C has survived. Cytokine study disclosed elevation of plasma CINC1, in addition to IL-6, TNF-alpha in plasma which was collected after bathing at 41 degree C for 3 hours, indicating activation of cytokine cascade is involved in this experimental model.

模拟日本的热浴诱发猝死，建立了一种新的大鼠高热模型并进行了挑战。在40摄氏度以上，老鼠很容易休克和死亡。血流动力学研究表明，过度高血压、心动过速和呼吸急促是初始事件，然后进展为休克和心脏骤停。虽然在使用42至43摄氏度空气室的大鼠中暑模型中已经报道了该序列，但液体作为传热介质比空气更快地传递热能，这表明该模型可以作为一种独特的模型，用于考虑日本每年造成14，000多人死亡的热水浸泡风险。水温超过40摄氏度，体温超过42摄氏度，是死亡的临界值。在停止加热时，体温超过43摄氏度的大鼠表现出休克并最终死亡，尽管那些低于42摄氏度的大鼠存活了下来。细胞因子研究揭示了在41 ℃下洗浴3小时后收集的血浆中除了IL-6、TNF-α外，血浆CINC 1也升高，表明该实验模型中涉及细胞因子级联的激活。