Basic study to establish the method to evaluate surface vascular lesions by utilization of optical coherence tomography.

建立利用光学相干断层扫描评估表面血管病变方法的基础研究。

• 批准号: 14370272
• 负责人: HAYASHI Naoto
• 金额: $ 8.26万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370272/
• 关键词: optic coherence tomography; optic fiber PZT phase modulator; arteriosclerotic changes; ultrasound tomography; infocus-coherence gate detection optic system; 動脈硬化; 血管壁; 光干渉; 超音波; 画像処理

This study was begun without means of obtaining the optic coherence tomography (OCT) system. The main supplier of OCT systems went under acquisition by another company. And at the same time, the OCT system was undergoing application for approval, which also prevented us from obtaining the OCT system. Though there was a major delay in the initiation of our research, we have managed to achieve the following results with the help from a research group in University of Osaka.We aimed to evaluate arteriosclerotic changes and diabetic changes of the surface arteries by a non-invasive method using OCT system. While the standard spatial resolution of OCT systems may be 10-20 micrometers, the maximum scanning distance is only one millimeter, so we selected the dorsal digital arteries as our measurement target since they are situated aright under the skin and easy to position under the OCT system. The experiment showed that the maximum scanning distance was insufficient even for the digital arteries and the localization of the arteries in the field of view was very difficult Consequently the depiction of the digital arteries was so poor that the optimization of the measurement process was not possible. To improve the scanning distance, we are now developing a new OCT system using 1.53-micrometer wave length laser and in-focus coherence gate detection optic system with the aid of a high-frequency ultrasound probe to localize the target in the field of view. And to minimize the effect of motion artifacts, we have tested a high-speed OCT system with an optic fiber PZT modulator in the low frequency inferometer.Our previous research have been mainly in the development of the hardware to measure surface arteries. We are now entering a new phase of our research to develop the software to apply the OCT system to clinical uses.

这项研究是在没有获得光学相干断层扫描（OCT）系统的情况下开始的。 OCT 系统的主要供应商被另一家公司收购。同时，OCT系统正在申请审批，这也阻碍了我们获得OCT系统。尽管我们的研究启动出现了重大延迟，但在大阪大学研究小组的帮助下，我们已经取得了以下成果。我们的目标是使用 OCT 系统通过非侵入性方法评估表面动脉的动脉硬化变化和糖尿病变化。虽然OCT系统的标准空间分辨率可能为10-20微米，但最大扫描距离仅为1毫米，因此我们选择指背动脉作为测量目标，因为它们位于皮肤正下方，易于在OCT系统下定位。实验表明，即使对于指动脉来说，最大扫描距离也不够，并且视野中动脉的定位非常困难，因此对指动脉的描绘很差，以至于无法优化测量过程。为了提高扫描距离，我们现在正在开发一种新型OCT系统，采用1.53微米波长激光和焦内相干门检测光学系统，并借助高频超声探头将目标定位在视场中。为了最大限度地减少运动伪影的影响，我们在低频干涉仪中测试了带有光纤 PZT 调制器的高速 OCT 系统。我们之前的研究主要集中在开发测量表面动脉的硬件。我们现在正进入研究的新阶段，开发将 OCT 系统应用于临床的软件。