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Construction of therapeutic gene library for pancreatic cancer and development of specific therapeutic vector

Construction of therapeutic gene library for pancreatic cancer and development of specific therapeutic vector
胰腺癌治疗基因库的构建及特异性治疗载体的开发
批准号:
14370345
负责人:
KATOH Hiroyuki
金额:
$9.02万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003

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中文摘要
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英文摘要
We constructed a frozen tissue library containing cancer tissues obtained from 5,000 patients who agreed with informed consent and underwent surgical treatment at Hokkaido University Hospital and its 33 affiliated hospitals. We had performed gene expression assay of 31 patients with pancreatic adenocarcinoma till December in 2003, and made the expression profile of 1289 genes correlated with cancer progression. On the other hand, we reported that several gene expression such as caveolin-1, RCAS1, and PEDF correlate with prognosis of patients with pancreatic cancer. We thought that PEDF gene therapy is potentially useful for the treatment of pancreatic cancer patients with liver metastasis.
期刊论文(26)
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会议论文
Hiraoka K: "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker"Int J Cancer. 99. 418-423 (2002)
Hiraoka K:“胰腺导管腺癌中肿瘤相关抗原 RCAS1 的高表达是一个不利的预后标志物”Int J Cancer。
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通讯作者:
Uehara H: "Expression of Pigment Epithelium-derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma"Cancer Res. (In Press).
Uehara H:“色素上皮衍生因子的表达可减少肝转移,并与导管胰腺腺癌患者的良好预后相关”Cancer Res。
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Hideaki Hashida: "Fusion of Tat protein transduction domain to poly-lysine as a new DNA delivery tool."British Journal of Cancer. 90. 1252-1258 (2004)
Hideaki Hashida:“Tat 蛋白转导结构域与聚赖氨酸的融合作为新的 DNA 传递工具。”英国癌症杂志。
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Hashida H: "Fusion of HIV-1 Tat protein transduction domain to poly-lysine as a new DNA delivery tool"Br J Cancer. 90. 1252-1258 (2004)
Hashida H:“HIV-1 Tat 蛋白转导结构域与聚赖氨酸的融合作为新的 DNA 传递工具”Br J Cancer。
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