Order-made medicine for cancer in the viewpoint of angiogenesis

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It has been thought that solid tumors require tumor angiogenesis in their growth. However, we sometimes encounter the tumors that grow rapidly despite their poor vascularity. This clinical observation suggest.s the existence of tumors that require little neoangiogenesis for their growth. In this research project, we analyzed the expressions of hexokinase, a key enzyme in glycolysis, and VEGE in hepatocellular carcinoma and rnetastatic liver cancer in relation to tumor vascularity, and the participation of hypoxia-inducible factor-1(HIF-1) was studied. Consequently, we obtained some informative evidence. In HCC, main energy source of the growth was derived from angiogenesis, whereas in metastatic tumors glycolysis induced by HIF-1 is the predominant energy source. In addition, it was suggested that cancer cells obtain energy for growth by switching the metabolic profile to glycolysis through HIP-i in hypoxic condition. Although many kinds of antiangiogenic therapies have been reported to be effective, it is assumed that some tumors might resist these therapies by acquiring energy for growth through increased glycolysis induced by HIF-1.