Molecular Pathological study of Carcinogenesis and behaeiviors of oral cancer.

口腔癌发生和行为的分子病理学研究。

• 批准号: 14370578
• 负责人: TAKAGI Minoru
• 金额: $ 6.53万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370578/
• 关键词: oral cancer; leukoplakia; human papilloma virus; papilloma; epidemiology; molecular pathology; carcinogenesis; immunohistocheniistry; 口腔癌; HPV

(1) Molecular pathological studies of human papilloma virus (HPV) of oral carcinoma, leukoplakia, papilloma, dysplasia were performed. The data of HPV was correlated with pathological behaviors of these lesions.(2) Epidemiological study was performed in the Miyakojiina Okinawa, in order to detect the percentage of HPV infection in the normal oral mucosa. The percentage of infection was low but rare types were discovered.(3) Prevalency of HPV in the oral cancer was studied in Myanmar, China and Sri-Lanka.(4) Interrelationship among HPV detection, betal quid and oral cancer was studied in Myanmar.

(1)对口腔癌、白斑、乳头状瘤、不典型增生组织中的人乳头状瘤病毒（HPV）进行了分子病理学研究。HPV检测结果与病变的病理行为相关。(2)在冲绳县宫古次名冲绳进行了流行病学调查，以检测正常口腔粘膜中HPV感染的百分比。感染的百分比很低，但发现了罕见的类型。(3)在缅甸、中国和斯里兰卡研究了口腔癌中HPV的患病率。(4)在缅甸研究了HPV检测、betal quid和口腔癌之间的相互关系。

项目成果

Nishioka M, Swe Swe Win, Ba Myint, Takagi M: "Detection of p53,Bax, Rb, p16 and human paillomavirus DNA in betel quid associated pral squamous cell carcinoma in Myammer."Oral Med Pathol. 8. 7-11 (2003)

Nishioka M、Swe Swe Win、Ba Myint、Takagi M：“在 Myammer 槟榔相关的普拉状细胞癌中检测 p53、Bax、Rb、p16 和人乳头状瘤病毒 DNA。”Oral Med Pathol。

Nishioka M, Swe Swe Win, Ba Myint, Takagi M.: "Detection of p53, Bax, Rb, p16 and human papillomavirus DNA in betel quid associated oral squamous cell carcinoma in Myanmar."Oral Med Pathol. 8. 7-11 (2003)

Nishioka M、Swe Swe Win、Ba Myint、Takagi M.：“缅甸槟榔相关口腔鳞状细胞癌中 p53、Bax、Rb、p16 和人乳头瘤病毒 DNA 的检测。”Oral Med Pathol。

Esgurerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M.: "Immunohisutochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma."Pathology International. 54. 82-89 (2004)

Esgurerra RL、Jia L、Kaneko T、Sakamoto K、Okada N、Takagi M.：“颊和牙龈鳞状细胞癌中着丝粒蛋白 F 表达的免疫组织化学分析。”国际病理学。

Nishioka M., Swe Swe Win, Ba Myint, Takagi M.: "Detection of p53, Bax, Rb, p16 and human papillomavirus DNA in Betel quid associated oral squamous cell carcinoma in Myanmar"Oral Med. Pathol.. (in print).

Nishioka M.、Swe Swe Win、Ba Myint、Takagi M.：“缅甸槟榔相关口腔鳞状细胞癌中 p53、Bax、Rb、p16 和人乳头瘤病毒 DNA 的检测”Oral Med。

Tang X, Jia L, Ouyang J, Takagi M.: "Comparative study of HPV prevalence in Japanese Northeast Chinese oral carcinoma."J Oral Pathol. 32. 393-398 (2003)

唐晓，贾琳，欧阳J，高木M.：“日本东北地区口腔癌HPV感染率的比较研究”。J Oral Pathol。