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Performance of a small semiconductor gamma camera for Radioguided Surgery

用于无线电引导手术的小型半导体伽马相机的性能

基本信息

批准号：
14370682
负责人：
HAYAMA Kazuhide
金额：
$ 9.09万
依托单位：
The Nippon Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370682/
关键词：
radiology USA : UK : Netherlands radioguided surgery sentinel lymph nodes biopsy lymph scintigraphy a semiconductor gamma camera a scintillation camera CdTe 国際研究者交流

项目摘要

A small semiconductor gamma camera (SSGC) for radioguided surgery provided better energy resolution than a conventional scintillation camera (CSC). Images obtained form a 20-mm-tall "S" figure phantom made from a 1-mm-diameter polyethylene tube and filled with 3OMBq Tc-99m, that was placed directly on the surfacee of each camera with a 2-s acquisition time. The image obtained by SSGC is much clearer than that obtained with a CSC, and so SSGC achieve high sensitivity and high spatial resolution.Preliminary clinical studies were performed, after institutional review boards approved the study protocol and informed consent was obtained from all patients. 116 patients with head and neck diseases (67 with malignant tumor, 4 with benign tumors, 5 with diseases of salivary gland, 4 with sialolith, 6 with xerostomia, 4 with sjogren syndrome, 9 with osteomyelitis, 6 with arthrosis of temporomandibular joint and 11 with another diseases) underwent scintigraphy using the SSGC and the CSC (bone sci … More ntigraphy were performed in 87 patients, salivary gland scintigraphy were performed in 21 patiens and lymph scintigraphy were performed in 8 patients). Preliminary clinical studies were successful in imaging in short acquisition time by using the SSGC. This SSGG provided better images than conventional scintillation camera. The activity ratio, the hot region to background (T/BG) ratio, was calculated in both gamma camera studies, T/BG ratio, by SSGC is the same as T/BG ratio by CSC.SSGC images were taken for 15,30 and 60 s, 30- and 60-s SSGC images clearly showed lymph nodes of patients who had breast cancer (by Hamamatsu University School of Medicine and Keio University School of Medicine), Esophageal cancer(by Keio University School of Medicine), laryngeal cancer (by Keio University School of Medicine), carcinoma of gingival(The Nippon Dental University) and carcinoma of tongue (The Nippon DentalUniversity) could be clearly visualized by the SSGC. The SSGC was able to resolve Lymph nodes of patients who had breast cancer (by Hamamatsu University School of Medicine), laryngeal cancer (by Keio University School of Medicine), even at a day after injection. The SSGC may offer advantage over current techniques for isolating sentinel lymph nodes for biopsy. A further potential application for this camera is in diagnosis, particularly of small, superficial lesions situated in tissues or organs such as the thyroid gland, jaws facial bones and joints. Less

用于放射导向手术的小型半导体伽马照相机（SSGC）提供了比传统闪烁照相机（CSC）更好的能量分辨率。用直径为1 mm的聚乙烯管制成高20 mm的“S”形体模，将30 MBq Tc-99 m注入体模，直接置于相机表面，采集时间为2 s。SSGC获得的图像比CSC获得的图像清晰得多，因此SSGC具有高灵敏度和高空间分辨率。在机构审查委员会批准研究方案并获得所有患者的知情同意后，进行了初步临床研究。本文对116例头颈部疾病（恶性肿瘤67例，良性肿瘤4例，涎腺疾病5例，涎石症4例，口腔干燥症6例，干燥综合征4例，骨髓炎9例，颞下颌关节炎6例，其他疾病11例）进行了SSGC和CSC骨显像，并与10例正常人进行了比较。 ...更多信息其中87例作了造影，21例作了涎腺造影，8例作了淋巴结造影。初步的临床研究成功地在短时间内通过使用SSGC成像。该SSGG提供了比传统闪烁相机更好的图像。两种γ照相机的T/BG比值（T/BG比值）的计算方法相同，SSGC的T/BG比值与CSC的T/BG比值相同。SSGC图像拍摄时间为15、30和60 s，30和60 s SSGC图像清晰显示乳腺癌患者的淋巴结（滨松大学医学部、庆应义塾大学医学部）食管癌（作者：庆应义塾大学医学部），喉癌（由庆应义塾大学医学院）、牙龈癌（日本齿科大学）和舌癌（日本齿科大学）可以通过SSGC清楚地可视化。SSGC能够解决乳腺癌（滨松大学医学院），喉癌（庆应义塾大学医学院）患者的淋巴结，甚至在注射后一天。SSGC可以提供优于目前的技术分离前哨淋巴结活检。该相机的另一个潜在应用是诊断，特别是位于组织或器官（如甲状腺、颌骨、面部骨骼和关节）中的小的浅表病变。少