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Clinical nuclear madicine by using small high resolution gamma camera in head and neck region

在头颈部使用小型高分辨率伽马相机进行临床核医学

基本信息

批准号：
17591975
负责人：
HAYAMA Kazuhide
金额：
$ 2.3万
依托单位：
The Nippon Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591975/
关键词：
radiology radioguided surgery sentinel lymph nodes biopsy lymph scintigraphy bone scintigraphy a semiconductor gamma camera CdTe a scintillation camera アメリカ

项目摘要

Small semiconductor gamma cameras(clinical type and trial type) for radioguided surgery provided better energy resolution than a conventional scintillation camera (CSC). Images obtained form a 20-mm-tall "S" figure phantom made from a 1-mm-diameter polyethylene tube and filled with 30MBq Tc-99m, that was placed directly on the surfacee of each camera with a 2-s acquisition time. The images obtained by clinical type and trial type were much clearer than that obtained with a CSC, and so clinical type and trial type achieve high sensitiveity and high spatial resolution. clinical type's performance is similar equal to trial type's it.Preliminary clinical studies were performed, after institutional review boards approved the study protocol and informed consent was obtained from all patients. 127 patients with head and neck diseases (72 with malignant tumor, 4 with benign tumors, 6 with diseases of salivary gland, 5 with sialolith, 7 with xerostomia, 4 with sjogren syndrome, 10 with osteomye … More litis, 7 with arthrosis of temporomandibular joint and 11 with another diseases) underwent scintigraphy using the gamma camera and the CSC (bone scintigraphy were performed in 93 patients, salivary gland scintigraphy were performed in 25 patiens and lymph scintigraphy were performed in 9 patiens). Preliminary clinical studies were successful in imaging in short acquisition time by using the gamma cameras. Gamma cameras provided better images than conventional scintillation camera. Gamma cameras images were taken for 15, 30 and 60 s, 30- and 60-s gamma cameras images clearly showed lymph nodes of patients who had breast cancer (by Hamamatsu University School of Medicine and Keio University School of Medicine), Esophageal cancer (by Keio University School of Medicine), laryngeal cancer (by Keio University School of Medicine), carcinoma of gingival (The Nippon Dental University), carcinoma of tongue (The Nippon Dental University) and prickle cell carcinoma (Niigata Cancer center Hospital) could be clearly visualized by the gamma cameras. In the International Clinical Trial study, Gamma camera's images were taken for 15 and 30 s, 30-s gamma camera's images showed clearly lymph nodes of patients (by John Wayne Cancer Institute, USA). The Gamma camera may offer advantage over current techniques for isolating sentinel lymph nodes for biopsy. A further potential application for this camera is in diagnosis, particularly of small, superficiall lesions situated in tissues or organs such as the thyroid gland, jaws facial bones and joints. Less

用于无线电引导手术的小型半导体伽马相机（临床型和试验型）提供了比传统闪烁相机（CSC）更好的能量分辨率。图像从 20 毫米高的“S”形模型获得，该模型由直径 1 毫米的聚乙烯管制成，填充有 30MBq Tc-99m，直接放置在每个相机的表面，采集时间为 2 秒。临床型和试验型获得的图像比CSC获得的图像清晰得多，因此临床型和试验型实现了高灵敏度和高空间分辨率。临床类型的表现与试验类型的表现相似。在机构审查委员会批准研究方案并获得所有患者的知情同意后，进行了初步临床研究。 127 例头颈部疾病患者（恶性肿瘤 72 例，良性肿瘤 4 例，唾液腺疾病 6 例，唾液腺疾病 5 例，口腔干燥症 7 例，干燥综合征 4 例，骨髓炎 10 例，颞下颌关节关节炎 7 例，其他疾病 11 例）使用伽马相机和 CSC（骨）进行闪烁扫描对 93 名患者进行了闪烁扫描，对 25 名患者进行了唾液腺闪烁扫描，对 9 名患者进行了淋巴闪烁扫描。初步临床研究成功地使用伽玛相机在短时间内获得成像。伽玛相机提供比传统闪烁相机更好的图像。伽玛相机图像拍摄时间为15秒、30秒和60秒，30秒和60秒伽玛相机图像清楚地显示了乳腺癌（滨松大学医学院和庆应义塾大学医学院）、食道癌（庆应义塾大学医学院）、喉癌（庆应义塾大学医学院）、牙龈癌（日本齿科大学）、舌癌患者的淋巴结（日本齿科大学）和棘细胞癌（新泻癌症中心医院）可以通过伽马相机清晰地观察到。在国际临床试验研究中，伽玛相机的图像拍摄时间为15秒和30秒，30秒伽玛相机的图像清晰地显示了患者的淋巴结（美国约翰韦恩癌症研究所）。伽玛相机可能比目前分离前哨淋巴结进行活检的技术更具优势。该相机的另一个潜在应用是诊断，特别是位于组织或器官（例如甲状腺、颌面部骨骼和关节）中的小型浅表病变。较少的

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

^<99m>Tc phytateを用いた口腔癌のセンチネルリンパ節シンチグラフィ

^<99m>使用 Tc 植酸盐进行口腔癌前哨淋巴结闪烁扫描

DOI：
发表时间：
2005
期刊：
日本口腔科学会雑誌 54
影响因子：
0
作者：
Tsuchimochi M;Hayama K;Sakahara H;Ohno R;Tsuchimochi M;土持眞
通讯作者：
土持眞

Role of Sentinel node biopsy in the management and staging of the No neck

前哨淋巴结活检在无颈的治疗和分期中的作用

DOI：
发表时间：
2005
期刊：
Odontology 93
影响因子：
0
作者：
Tsuchimochi M;Hayama K;Sakahara H;Ohno R;Tsuchimochi M;土持眞;藤井博史;Fujii H;Gary L. Ross
通讯作者：
Gary L. Ross

Tc-99m phytate sentinel node lymphoscintigraphy in oral cancer patients

口腔癌患者的 Tc-99m 植酸前哨淋巴结淋巴闪烁显像

DOI：
发表时间：
2005
期刊：
Journal of the Japanese Stomatological society 54. 3
影响因子：
0
作者：
Tsuchimochi M;Hayama K;Oda T;Sue M;Katada T;Sasaki Y;Toyama M;Kuroiwa H;Yamaguchi A;Mataga I;Tsuchikawa K
通讯作者：
Tsuchikawa K

口腔領域における画像診断の新たな展開センチネルリンパ節の画像診断

口腔影像诊断新进展前哨淋巴结影像诊断