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Development of intrauterine endoscopic surgical tools at early stage during pregnancy

妊娠早期宫腔镜手术工具的研制

基本信息

批准号：
14390007
负责人：
HAGA Yoichi
金额：
$ 8.38万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14390007/
关键词：
intrauterine surgery embryo minimally invasive surgery laser treatment ultrasound マイクロスキャナー

项目摘要

Surgery of fetus and embryo is being shifted from open fetal surgery to fetoscopic procedure. In this research, several endoscopic surgical tools have been developed for intrauterine endoscopic surgery at early stage during pregnancy, for example, ultrasonic endoscope for observation of fetus and embryo, micro laser scanning tool and focused ultrasonic probe as treatment tools.For precise laser treatment in uterus, a 2D (two dimensional) laser scanning micro tool has been developed. The tool is made up of an optical fiber, a micro rod lens and a 2D microscanner. The 2D microscanner has three piezoelectric unimorph cantilevers. The mirror is supported by a pivot from underside and is inclined by pushing down by three cantilevers on the top of the mirror. Scanning of 100-um-diameter spot of KTP laser was confirmed. For insertion the tool into a working channel of a conventional endoscope, these components are packaged into a 3.8-mm-external-diameter polymer tube. As ultrasonic tools, convex-shaped 8 ring array ultrasonic imager of 3-mm-diameter and concave-shaped ultrasonic transducer for ultrasonic treatment have been developed. Each transducer of the imager can detect echo signal from an aluminum board in water. Imaging of tissue in the fetus / embryo will be tested. A 6-mm-diameter ultrasonic treatment tool has been fabricated and power generation of ultrasound at intensity for treatment was confirmed.

胎儿和胚胎的手术正从开放性胎儿手术转向胎儿镜手术。本研究针对妊娠早期宫腔镜手术，研制了用于胎儿和胚胎观察的超声内窥镜、微型激光扫描工具和聚焦超声探头等内窥镜手术工具;针对子宫内精确激光治疗，研制了二维激光扫描微型工具。该仪器由光纤、微棒透镜和二维微扫描仪组成。二维微扫描仪具有三个压电单晶片杠杆。镜子由一个枢轴从下面支撑，通过镜子顶部的三个杠杆向下推而倾斜。确定了KTP激光器100 μ m光斑的扫描范围。为了将工具插入到传统内窥镜的工作通道中，这些部件被封装到3.8 mm外径的聚合物管中。作为超声工具，已开发出直径3 mm的凸形8环阵列超声成像仪和用于超声治疗的凹形超声换能器。成像仪的每个换能器可以检测水中铝板的回波信号。将对胎儿/胚胎中的组织成像进行测试。已经制造了直径为6 mm的超声波治疗工具，并确认了治疗强度的超声波发电。