Neurophysiological study to reveal the relationship between sleep bruxism and gastroesophageal reflux (GER).

神经生理学研究揭示睡眠磨牙症与胃食管反流（GER）之间的关系。

• 批准号: 15390634
• 负责人: MIYAWAKI Shouichi
• 金额: $ 8.32万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390634/
• 关键词: Bruxism; pH-metry; Manometry; RMMA(Rhysmic masticatory mascle activity); Temporomandibular disorder; Polysomnography; electromyogram(EMG); electroencephalogram(EEG)

Ten bruxism patients and 10 normal adults were used as subjects and they were matched for height, weight, age and sex. They did not have GER disease symptoms.The bruxism group showed a significantly higher frequency of nocturnal bruxism episodes and a higher frequency and percentage of time of gastroesophageal reflux(GER) episodes with pH<4.0 and 5.0 than the control group. In the bruxism group, 100% of the GER episodes with pH<3.0 and 4.0 included both an RMMA episode and EMG burst whose duration was around 0.5 to 1.0 second, probably representing saliva swallowing. The majority of GER episodes with a pH of 4.0-5.0 also included both an RMMA episode and EMG burst, again probably due to saliva swallowing in the control and bruxism groups. The remaining minority of GER episodes with a pH of 4.0-5.0 contained only an EMG burst (saliva swallowing). The frequency of RMMA episodes after the PPI medication, which increased the gastric and esophageal pH, was significantly lower than that after the placebo medication in the control and bruxism groups.Nocturnal bruxism may be secondary to nocturnal GER, occurring via sleep arousal, and often together with swallowing. The physiologic link between bruxism and increase in salivation needs to be investigated.

以10例磨牙症患者和10例正常成人为研究对象，身高、体重、年龄、性别匹配。磨牙症组夜间磨牙症发作频率明显高于对照组，胃食道反流(GER)发作的频率和时间百分比高于对照组。在磨牙症组，pH和lt；3.0和4.0的GER发作100%都包括RMMA发作和EMG爆发，持续时间约为0.5-1.0秒，可能代表吞咽唾液。大多数pH为4.0-5.0的GER发作还包括RMMA发作和EMG爆发，同样可能是由于对照组和磨牙症组的唾液吞咽。其余少数pH为4.0-5.0的GER发作仅有肌电爆发(唾液吞咽)。在对照组和磨牙症组中，PPI治疗后胃和食道pH值升高的RMMA发作频率明显低于安慰剂治疗后。夜间磨牙症可能继发于夜间GER，通过睡眠唤醒而发生，通常与吞咽一起发生。磨牙症和唾液增多之间的生理联系需要调查。

项目成果

Miyawaki, S.: "Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage"American Journal of Orthodontics and Dentofacial Orthopedics. 124. 373-378 (2003)

Miyawaki, S.：“与放置在后牙区正畸支抗的钛螺钉稳定性相关的因素”美国正畸学和牙面矫形外科杂志。

Association between nocturnal bruxism and gastroesophageal reflux

• DOI: 10.1093/sleep/26.7.888
• 发表时间: 2003-11-01
• 期刊: SLEEP
• 影响因子: 5.6
• 作者: Miyawaki, S;Tanimoto, Y;Takano-Yamamoto, T
• 通讯作者: Takano-Yamamoto, T

Salivary flow rates during relaxing, clenching and chewing-like movement with maxillary occlusal splints.

使用上颌牙合夹板进行放松、咬紧和咀嚼样运动时的唾液流量。

• 发表时间: 2004
• 期刊: Am J Orthod.Dentofac Orthop 126(3)
• 作者: Miyawaki;S.et al.
• 通讯作者: S.et al.

Miyawaki, S.: "Association between noctumal brnxism and gastroesophageal reflux"Sleep. 26. 888-892 (2003)

Miyawaki, S.：“夜间夜食症与胃食管反流之间的关联”睡眠。

Relatioships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positions.

夜间下颌肌肉活动、食道 pH 值降低和睡眠姿势之间的关系。

• 发表时间: 2004
• 期刊: Am J Orthod.Dentofac Orthop 126(5)
• 作者: Miyawaki;S.et al.
• 通讯作者: S.et al.