Respiratory and Cardiovascular Activation at Arousal from Sleep

从睡眠中醒来时呼吸和心血管的激活

• 批准号: DP0558813
• 负责人: Prof John Trinder
• 金额: $ 16.92万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558813
• 关键词: Respiratory; Cardiovascular; Activation; Arousal; Sleep

An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now apparent, the mechanism that causes the increase in physiological activity at each arousal, is not known. The aim of this project will provide insight into the mechanism that produces the activation response and provide a basis for minimising the cardiac consequences of sleep disorders.

从睡眠中唤醒，无论多么短暂，都与呼吸系统和心脏系统的活动增加有关。在正常情况下，这种反应被认为是适应性的。然而，在个人频繁唤醒和睡眠支离破碎的睡眠障碍中，例如阻塞性睡眠呼吸暂停，这种现象与高血压有关。虽然睡眠碎片化的临床后果现在已经很明显，但导致每次唤醒时生理活动增加的机制尚不清楚。该项目的目的将提供对产生激活反应的机制的洞察，并为将睡眠障碍的心脏后果降至最低提供基础。