Development of regenerative medicine for chronic pain: novel treatment with cell transplantation and drug delivery system.

慢性疼痛再生医学的发展：细胞移植和药物输送系统的新型治疗方法。

• 批准号: 16H02678
• 负责人: SAITO SHIGERU
• 金额: $ 23.63万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16H02678/
• 关键词: 慢性疼痛; 再生医療; 抑制ニューロン; 脊髄後角; 神経障害性疼痛; 慢性痛

项目成果

Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain

慢性神经病理性疼痛大鼠模型中内源性镇痛的丧失导致切口痛恢复延迟

• DOI: 10.1016/j.brainres.2019.146568
• 发表时间: 2020
• 期刊: Brain Res
• 影响因子: 2.9
• 作者: Ohta J;Suto T;Kato D;Hiroki T;Obata H;Saito
• 通讯作者: Saito

Brain morphological alternation in chronic pain patients with neuropathic characteristics.

• DOI: 10.1177/1744806916652408
• 发表时间: 2016
• 期刊: Molecular pain
• 影响因子: 3.3
• 作者: Sugimine S;Ogino Y;Kawamichi H;Obata H;Saito S
• 通讯作者: Saito S

Spinal Activation of Tropomyosin Receptor Kinase-B Recovers the Impaired Endogenous Analgesia in Neuropathic Pain Rats

• DOI: 10.1213/ane.0000000000003592
• 发表时间: 2019-08-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Kato, Daiki;Suto, Takashi;Saito, Shigeru
• 通讯作者: Saito, Shigeru

Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats

• DOI: 10.1213/ane.0000000000001301
• 发表时间: 2016-08-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Matsuoka, Hiroaki;Suto, Takashi;Obata, Hideaki
• 通讯作者: Obata, Hideaki

Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats

• DOI: 10.1016/j.jpain.2018.11.008
• 发表时间: 2019-05-01
• 期刊: JOURNAL OF PAIN
• 影响因子: 4
• 作者: Suto, Takashi;Kato, Daiki;Saito, Shigeru
• 通讯作者: Saito, Shigeru