The role of pandemic and individual vulnerability in longitudinal cohorts across the life span: refined models of neurosociobehavioral pathways into substance (ab)use?

个人对危险行为的决定，如物质消耗，会受到神经行为微状态的影响，包括冲动或适应不良的应激反应。然而，这些决定也归因于社会情感暗示--从宏观社会规范和机会，包括出入路线或私人空间，到中观社会因素，包括与消费同龄人的亲密程度或家庭压力。新冠肺炎疫情引发了许多限制，并导致每个年龄段不同装备的个人的社会功能发生了变化，我们可能需要完善之前确定的规范性和非规范性冒险轨迹，以预测药物使用。利用现有的纵向队列研究(IMAGEN、ROLS、MARS)和横断面拟合的高分辨率真实瞬时数据(IMAC-Mind)，其中在封锁期间添加了与新冠肺炎相关的健康/社会行为评估，我们将进行多变量分析，估计新冠肺炎下的措施的稳定性以及随着时间的推移的关系。我们将评估样本中新的大脑和基于传感器的日常行为数据，以捕获冒险/感知、纵向锁定后以及情感调节(正念)的关键特征和交叉验证年龄数据。被确定为保护性分类的因素可能会削弱或加强，可能会出现新的关键机制关联，包括更大的性别差异。我们可以在人的一生中的合理时期对大流行的健康后果有价值的洞察。

Individual decisions for risky behavior, such as substance consumption, are influenced by neurobehavioral microstates, including impulsivity or maladaptive stress reactivity. These decisions have, yet, also been attributed to socioaffective cues - from macrosocial norms and opportunities, including access routes or private space, to mesosocial factors, including closeness to consuming peers or amount of familial stress. The COVID-19 pandemic provoked many restrictions and changes in social functioning along differently equipped individuals in every age cohort, and we might need to refine previously identified normative and nonnormative risk-taking trajectories for substance use prediction. Capitalizing on existing longitudinal cohort studies (IMAGEN, ROLS, MARS) and cross-sectionally fitted high-resolution real-life momentary data (IMAC-Mind), where COVID-19-related health/sociobehavioral assessments have been added during the lockdown, we will perform multivariate analyses estimating the stability of measures under COVID-19 and relations over time. We will asses new brain and daily, sensor-based behavioral data in the samples to capture risk-taking/perceptions, longitudinally after-lockdown, and key features of affect regulation (mindfulness) and cross-validate age data. Factors established as protective classifiers might weaken or strengthen and new key associations of mechanisms might exhibit, including even stronger gender differences. We may gain valuable insight into pandemic health consequences in sensible periods along the life span.