GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression)

项目摘要 基因组学已成为生物医学科学的一个基本要素，在快速解决生物医学领域中发挥着多种作用。 COVID-19大流行，了解医疗并发症，以开发更有效的预防护理和治疗， 并在实验室标本中模拟疾病以供研究。尽管基因组学与人类的 日常生活中，美国的基因组学素养仍然很低。此外，美国的基因组学工作人员 国家仍然远远没有实现NHGRl关于多样性的战略愿景。为了满足这些社会需求， 让人们接触基因组学职业，并在他们思考未来时对他们进行相关主题的教育， 职业道路。为了最大限度地发挥这种努力的影响，高中和本科生需要 获得更高质量的基因组学教育，以培养他们对追求基因组学职业的兴趣，并提高他们的 基因组学工作人员的多样性。 为了满足这一关键需求，SIFT、科尔比学院和杰克逊实验室提出了GENOMICE（游戏探索细微差别 在后代掌握染色体表达的相互作用），一个低成本的，基于网络的数字游戏，教大学 和高中生思考基因组学定量，概率，并通过积极的预测， 参与，战略性问题解决和定制的反馈，模仿基因组学教师如何教他们的学生。 非暴力的游戏和代表多样性的许多方面的人物将呈现一个包容性的 环境设计，以吸引学生，无论他们的经验玩游戏。 这个小企业技术转让（STTR）项目的第一阶段将产生一个低保真原型， 演示特定的游戏机制，旨在教授核心基因组学概念：识别表型，预测 基因型，并制定育种策略，选择性地产生后代种群和性状（目标1）。 GENOMICE还将包括一个尖端的人工智能（AI）系统，可以监控玩家的表现， 适当修改游戏内容以提高学习效果（目标2）。GENOMICE的低保真原型将是 在基因组学入门课程中与大学生进行的一项试点研究中， (AIM 3）。 GENOMICE将成为第一个针对核心基因组学的可扩展、基于游戏的自适应基因组学教育工具 概念和促进游戏中学习的传统基因组学评估的转移。GENOMICE将是一个基于网络的 游戏，允许轻松设置和可扩展性，无论个人计算机的能力。制作基因组 商业上可用于大学，基因组学研究机构，高中和基因组学行业， 提高学生参与基因组学的潜力，并为所有背景的学生提供所需的技能， 未来的基因组学事业

PROJECT SUMMARY Genomics has become an essential element of biomedical science, playing multiple roles in rapidly addressing the COVID-19 pandemic, understanding medical complications to develop more effective preventative care and treatments, and modeling diseases in laboratory specimens for study. Despite the increasing relevance of genomics to people's everyday lives, genomics literacy in the United States remains low. In addition, the genomics workforce in the United States is still far from achieving the NHGRl's Strategic Vision with respect to diversity. To address these societal needs, it is critical to expose people to genomics careers and educate them on related topics while they contemplate future career pathways. To maximize the impact of such an effort, students at the high school and undergraduate level need access to a higher-quality genomics education to seed their interest in pursuing genomics careers and improve the diversity of the genomics workforce. To meet this critical need, SIFT, Colby College, and Jackson Labs propose GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression), a low-cost, web-based digital game that teaches college and high school students to think about genomics quantitatively, probabilistically, and predictively through active engagement, strategic problem-solving, and customized feedback emulating how genomics instructors teach their students. Non-violent gameplay and characters representative of many dimensions of diversity will present an inclusive environment designed to appeal to students regardless of their experiences playing games. Phase I of this Small Business Technology Transfer (STTR) project will produce a low-fidelity prototype with tasks demonstrating specific game mechanics designed to teach core genomics concepts: identifying phenotypes, predicting genotypes, and developing breeding strategies to selectively produce offspring populations and traits (Aim 1 ). GENOMICE will also include a cutting-edge artificial intelligence (Al) system that monitors player performance and appropriately modifies game content to improve learning outcomes (Aim 2). GENOMICE's low-fidelity prototype will be evaluated in terms of usability and enjoyability in a pilot study with college students in introductory genomics courses (AIM 3). GENOMICE will be the first scalable, game-based, and adaptive genomics education tool targeting core genomics concepts and promoting transfer of in-game learning to traditional genomics assessments. GENOMICE will be a webbased game, allowing easy set up and scalability regardless of individual computers' capabilities. Making GENOMICE commercially available to universities, genomics research institutions, high schools, and the genomics industry has the potential to increase student engagement with genomics and give students of all backgrounds the skills needed for future genomics careers.