GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression)

项目总结 基因组学已成为生物医学科学的基本要素，在快速解决 新冠肺炎大流行，了解医疗并发症，开发更有效的预防性护理和治疗， 并在实验室标本中模拟疾病以供研究。尽管基因组学与人们的 在日常生活中，美国的基因组学素养仍然很低。此外，美国的基因组学工作人员 各国仍远未实现NHGR1关于多样性的战略愿景。为了满足这些社会需求， 在人们思考未来的同时，让他们接触基因组学职业，并就相关主题进行教育是至关重要的 职业道路。为了最大限度地发挥这种努力的影响，高中生和本科生需要 获得更高质量的基因组学教育，以培养他们追求基因组学事业的兴趣，并提高 基因组学劳动力的多样性。 为了满足这一关键需求，SIFT、科尔比学院和杰克逊实验室提出了GENOMICE(游戏探索细微差别 在《染色体表达的后代与大师的相互作用》中)，这是一款低成本、基于网络的数字游戏，面向大学 和高中生通过积极的定量、概率和预测性地思考基因组学 参与性、战略性问题解决和定制反馈，模仿基因组学教师教授学生的方式。 非暴力的游戏性和代表多样性的多个维度的角色将呈现出包容性 为吸引学生而设计的环境，无论他们玩游戏的经历如何。 该小型企业技术转移(STTR)项目的第一阶段将生产具有任务的低保真原型 演示旨在教授核心基因组学概念的特定游戏机制：识别表型、预测 基因分型，以及制定有选择地产生后代群体和性状的育种战略(目标1)。 GENOMICE还将包括一个尖端的人工智能(Al)系统，它可以监控玩家的表现和 适当修改游戏内容以提高学习效果(目标2)。GENOMICE的低保真原型将是 在对大学生进行的基因组学入门课程的试点研究中，对可用性和趣味性进行了评估 (目标3)。 GENOMICE将是第一个针对核心基因组学的可扩展、基于游戏和适应性的基因组学教育工具 概念和促进将游戏中的学习转移到传统的基因组学评估。GENOMICE将是一个基于Web的 游戏，无论单个计算机的功能如何，都可以轻松设置和扩展。制作通用字 可供大学、基因组研究机构、高中和基因组学行业商业使用的 有潜力提高学生对基因组学的参与度，并为所有背景的学生提供所需的技能 未来的基因组学事业。

PROJECT SUMMARY Genomics has become an essential element of biomedical science, playing multiple roles in rapidly addressing the COVID-19 pandemic, understanding medical complications to develop more effective preventative care and treatments, and modeling diseases in laboratory specimens for study. Despite the increasing relevance of genomics to people's everyday lives, genomics literacy in the United States remains low. In addition, the genomics workforce in the United States is still far from achieving the NHGRl's Strategic Vision with respect to diversity. To address these societal needs, it is critical to expose people to genomics careers and educate them on related topics while they contemplate future career pathways. To maximize the impact of such an effort, students at the high school and undergraduate level need access to a higher-quality genomics education to seed their interest in pursuing genomics careers and improve the diversity of the genomics workforce. To meet this critical need, SIFT, Colby College, and Jackson Labs propose GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression), a low-cost, web-based digital game that teaches college and high school students to think about genomics quantitatively, probabilistically, and predictively through active engagement, strategic problem-solving, and customized feedback emulating how genomics instructors teach their students. Non-violent gameplay and characters representative of many dimensions of diversity will present an inclusive environment designed to appeal to students regardless of their experiences playing games. Phase I of this Small Business Technology Transfer (STTR) project will produce a low-fidelity prototype with tasks demonstrating specific game mechanics designed to teach core genomics concepts: identifying phenotypes, predicting genotypes, and developing breeding strategies to selectively produce offspring populations and traits (Aim 1 ). GENOMICE will also include a cutting-edge artificial intelligence (Al) system that monitors player performance and appropriately modifies game content to improve learning outcomes (Aim 2). GENOMICE's low-fidelity prototype will be evaluated in terms of usability and enjoyability in a pilot study with college students in introductory genomics courses (AIM 3). GENOMICE will be the first scalable, game-based, and adaptive genomics education tool targeting core genomics concepts and promoting transfer of in-game learning to traditional genomics assessments. GENOMICE will be a webbased game, allowing easy set up and scalability regardless of individual computers' capabilities. Making GENOMICE commercially available to universities, genomics research institutions, high schools, and the genomics industry has the potential to increase student engagement with genomics and give students of all backgrounds the skills needed for future genomics careers.