Signaling and functions of CDM family proteins that acts as Rac GEFs
Signaling and functions of CDM family proteins that acts as Rac GEFs
批准号:
22247017
负责人:
FUKUI Yoshinori
金额:
$27.54万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In this study, we have analyzed signaling and functions of CDM family proteins that are known to act as Rac GEFs. We obtained several important conclusions as follows:1) DOCK1 acts downstream of CXCR4 in endothelial cells and plays an important role in cardiovascular development.2) DOCK2 regulates NK cell-mediated cytotoxicity.3) DOCK5 plays an important role in osteoclast functions.4) DOCK1 is required for PDGF-induced dorsal ruffle formation.5) Unlike DOCK5, DOCK1 and DOCK2 bind to phosphatidic acid.
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Signaling and function of the CDM family protein DOCK2.
CDM 家族蛋白 DOCK2 的信号传导和功能。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Melin, A.D., Moritz, G.L., Fosbury, R.A.E., Kawamura, S., Dominy, N.J., Fukui Y]
通讯作者:
Fukui Y
免疫系細胞高次機能を司るCDM ファリー分子DOCK2 -その分子基盤と創薬への応用-
DOCK2,一种控制免疫系统细胞高级功能的CDM家族分子-其分子基础及其在药物发现中的应用-
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[柏崎隼, 高木智子, 馬渕一誠, 福井宣規]
通讯作者:
福井宣規
樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8
DOCK8,一种控制树突状细胞三维运动的 Cdc42 激活分子
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Fujimoto, H., Mabuchi, I., 黒岩常祥, 田中芳彦 他]
通讯作者:
田中芳彦 他
Structural basis of functional complex formation between DOCK2 and ELMO1
DOCK2和ELMO1之间形成功能复合物的结构基础
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Watanabe M, et al]
通讯作者:
et al
心血管形成におけるDOCK180の機能とその制御機構、感染・炎症・免疫、42
DOCK180在心血管形成中的作用及其调控机制,感染/炎症/免疫,42
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[實松史幸, 福井宣規]
通讯作者:
福井宣規
共 53 条
The role of DOCK2 and its regulatory mechanism in the innate immune system
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批准号:18390154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.18万
-
财政年份:2006
-
负责人:FUKUI Yoshinori
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依托单位:
Role of the phosphatidylserine receptor in development of hematopoietic cells
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批准号:16390144
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2004
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负责人:FUKUI Yoshinori
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依托单位:
Role of the CDM family proteins in the immune surveillance.
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批准号:16043239
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$25.34万
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财政年份:2004
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负责人:FUKUI Yoshinori
-
依托单位:
Role of the CDM family protein DOCK2 in lymphocyte functions
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批准号:14370113
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:2002
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负责人:FUKUI Yoshinori
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依托单位:
Identification of the ligand recognized by a mAb specific for CD4^+CD8^+ thymocyte
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批准号:11670325
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1999
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负责人:FUKUI Yoshinori
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依托单位:
Molecular basis for T cell repertoire selection in the thymus
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批准号:11694289
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.35万
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财政年份:1999
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负责人:FUKUI Yoshinori
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依托单位:
Molecular analysis for TCR-MHC-peptide interaction in thymic selection in vitro and in vivo
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批准号:08839017
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1996
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负责人:FUKUI Yoshinori
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依托单位:
海外基金