Dynamics of stress-homeosurveillance and its relevance to disease control

应激同源监测的动态及其与疾病控制的相关性

• 批准号: 22249025
• 负责人: TANAKA Yoshiya
• 金额: $ 30.2万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22249025/
• 关键词: ストレス科学; ホメオサーベイランス; 酸化ストレス; 生存脳; 神経伝達物資; 免疫伝達物質; 神経伝達物質; 免疫系; 代謝系; ストレス

Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.

通过压力传感器接收输入信号，并向代谢和免疫系统发送输出信号，进行重要的体内监测。本研究通过阐明(1)应激感知（如疼痛、机械和氧化应激）向包括下丘脑在内的重要脑中枢的输入信号机制，以及(2)生理状态和疾病模型中从脑中枢向免疫、炎症和骨代谢系统的输出信号机制，来阐明同质监测中的动态。通过PTH/PTHrP和合成神经元输出信号，使干细胞或naïve细胞向特定方向分化，参与疾病进程。此外，利用调节自身监测动态的疾病模型的结果将带来新的疾病控制策略。

项目成果

Shorter unipedal standing time and lower bone mineral density in women with distal radius fractures.

患有桡骨远端骨折的女性单足站立时间较短，骨矿物质密度较低。

• 发表时间: 2010
• 期刊: Osteoporos Int 21
• 作者: Sakai A;Nakamura T;et al.
• 通讯作者: et al.

Post–Hoc Analysis Showing Better Clinical Response With The Loading Dose Of Certolizumab Pegol In Japanese Patients With Active Rheumatoid Arthritis.

事后分析显示，负荷剂量的 Certolizumab Pegol 对日本活动性类风湿关节炎患者有更好的临床反应。

• 发表时间: 2013
• 作者: Tsutomu Takeuchi;Kazuhiko Yamamoto;Hisashi Yamanaka;Naoki Ishiguro;Yoshiya Tanaka;Katsumi Eguchi;Akira Watanabe;Hideki Origasa;Mariko Kobayashi;Toshiharu Shoji;Nobuyuki Miyasaka and Takao Koike.
• 通讯作者: Nobuyuki Miyasaka and Takao Koike.

A LARGE-SCALE PROSPECTIVE SINGLE COHORT STUDY OF WORK PRODUCTIVITY AND ACTIVITY IMPAIRMENT IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING ADALIMUMAB: ANALYSIS OF 24-WEEKS DATA FROM THE ANOUVEAU STUDY

接受阿达木单抗治疗的日本类风湿性关节炎患者工作效率和活动受损的大规模前瞻性单队列研究：ANOUVEAU 研究的 24 周数据分析

• 发表时间: 2013
• 作者: T Takeuchi;S. Komatsu;T. Muramatsu;T. Kubo;A. Kuroki;T. Tango;Y. Tanaka.
• 通讯作者: Y. Tanaka.

WEEK 12 CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL PREDICTS LONG-TERM OUTCOMES REGARDLESS OF CONCOMITANT MEDICATIONS AND BASELINE DISEASE CHARACTERISTICS IN JAPANESE PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS

第 12 周，CERTOLIZUMAB PEGOL 的临床反应可预测日本活动性类风湿性关节炎患者的长期结果，无论是否同时服用药物和基线疾病特征

• 发表时间: 2013
• 作者: H. Yamanaka;K. Yamamoto;T. Takeuchi;N. Ishiguro;Y. Tanaka;K. Eguchi;A. Watanabe;H. Origasa;T. Shoji;S. Onodera;N. Miyasaka.
• 通讯作者: N. Miyasaka.

A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-_Y and IL-17 production by human CD4+ T cells

JAK 抑制剂托法替布通过抑制人 CD4 T 细胞产生 IFN-_Y 和 IL-17 来调节滑膜炎

• 发表时间: 2012
• 期刊: Arthritis Rheum
• 作者: Maeshima K;Yamaoaka K;Kubo S;Nakano K;Iwata S;Tanaka Y;et al
• 通讯作者: et al