Dynamics of stress-homeosurveillance and its relevance to disease control

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Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.