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Stress-surveillance and signal network originated from dendrite of various cells

Stress-surveillance and signal network originated from dendrite of various cells
源自各种细胞树突的压力监视和信号网络
批准号:
18209026
负责人:
TANAKA Yoshiya
金额:
$31.45万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2009

项目摘要

项目成果

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相关文献

中文摘要
翻译
“树突”表达于中枢神经系统和外周神经元、免疫系统树突细胞、皮肤朗格汉斯细胞、骨组织骨细胞等多种细胞上,接受多种应力,作为应力监测传感器发挥作用。具有树突的细胞接受应激刺激后,通过核转录将其转化为多种胞内信号,并将这些信号传递给人体中枢神经、免疫、皮肤、代谢等系统中的各种防御细胞功能。因此,我们推测树突作为一个中枢感受器,通过启动多种应激刺激在自我防御系统中起着关键作用。
英文摘要
"Dendrite" is expressed on various cells including neuron in CNS and periphery, dendritic cells in immune system, Langerhans cells in skin, osteocyte in bone and so on. The dendrite receives multiple stresses and functions as stress-surveillance sensors. The cells possessing the dendrite receive stress-stimulation, transform it to multiple intracellular signals through nucleic transcription and transduce the signals to various defensive cellular functions in central nerve, immune, skin, metabolic systems in human body. Thus, we postulate that the dendrite plays a pivotal role in the self-defense system through initiating multiple stress-stimulation as a central sensor.
期刊论文(109)
专著(0)
科研奖励(0)
会议论文
The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somato/dendritic peptide release.
apelin 对下丘脑大细胞加压素和催产素神经元电活动以及体细胞/树突肽释放的影响。
DOI: --
发表时间: 2008
期刊: Endocrinology 149(12)
影响因子: --
作者: [Tobin, A. V., Bull, P. M., Aruna chalam, S., O'Carroll, A. -M., Ueta, Y., Ludwig, M.]
通讯作者: M.
Arsenic trioxide augments chk2/p53-mediated apoptosis by inhibiting oncogene wip1 phosphatase.
三氧化二砷通过抑制癌基因 wip1 磷酸酶来增强 chk2/p53 介导的细胞凋亡。
DOI: --
发表时间: 2008
期刊: J Biol Chem 283
影响因子: --
作者: [Yoda A, Toyoshima K, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.]
通讯作者: Minami Y.
The oral Jak inhibitor CP-690, 550 in combination with methotrexate is efficacious, safe and well tolerated in Japanese patients with active rheumatoid arthritis with an inadequaet response to MTX alone.
口服 Jak 抑制剂 CP-690、550 与甲氨蝶呤联合治疗对单独使用 MTX 反应不足的活动性类风湿关节炎日本患者有效、安全且耐受性良好。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Y. Tanaka, M. Suzuki, H. Nakamura, S. Toyoizumi, S.H. Zwillich.]
通讯作者: S.H. Zwillich.
Inhibitory effects of epinastine on chemokine production and MHC class II/CD54 expression in keratinocytes.
Epinastine 对角质形成细胞中趋化因子产生和 MHC II 类/CD54 表达的抑制作用。
DOI: --
发表时间: 2007
期刊: Journal of Dermatological Science 45.2
影响因子: --
作者: [Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O, Nanba E, Nishida H, Sugiyama T, Kasai K, Watanabe K, Kano Y, Kato N, Sasaki T, Kobayashi M.]
通讯作者: Kobayashi M.
共 85 条
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    Identification of organ-specific cell surface molecules on T cells and endothelial cells in patients with systemic lupus erythematosus
    The functional heterogeneity of synovial cells in patients with rheumatoid arthritis.
    Heparan sulfate proteoglycan on leukemic cells is primarily involved in integrin-triggering and its mediated adhesion to endothelial cells.
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