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Recapitulation of phenotypes and discovery of a novel treatment with disease-specific human ES/ iPS cells from various hereditary diseases

Recapitulation of phenotypes and discovery of a novel treatment with disease-specific human ES/ iPS cells from various hereditary diseases
重述表型并发现来自各种遗传性疾病的疾病特异性人类 ES/iPS 细胞的新疗法
批准号:
22249042
负责人:
NAKAHATA Tatsutoshi
金额:
$30.87万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

NAKAHATA Tatsutoshi的其他基金

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相关文献

中文摘要
翻译
我们致力于从各种遗传性疾病患者的体细胞中培养出iPS细胞,并诱导这些iPS细胞适当分化为病变器官的细胞,从而阐明疾病的病因和发病机制。我们用传统的逆转录病毒方法成功地从先天性中性粒细胞减少症、Duchenne肌营养不良症、CINCA综合征、Nakajyo-Nishimura综合征、脊髓性肌萎缩症、Chediak-Higashi综合征、先天性巨结肠患者中分离出了疾病特异性的iPS细胞。我们在皮肤成纤维细胞阶段没有收集基因的情况下,未能从Fanconi贫血和网状发育不全的患者中产生iPS细胞。我们已经证实了几种疾病特异性iPS细胞的表型重现,包括CINCA综合征、网状发育不全和Chediak-Higashi综合征。
英文摘要
We were engaged in research to generate iPS cells from somaticcells of patients with various hereditary diseases, induced these iPS ells to differentiate appropriately into the cells the diseased organs,and thereby elucidate the etiology and the mechanisms of the diseases. We succeeded the generation of disease-specific iPS cells from patients with congenital neutropenia, Duchenne muscular dystrophy, CINCA syndrome, Nakajyo-Nishimura syndrome, spinal muscular atrophy, Chediak-Higashi syndrome, Hirschsprung disease by using conventional retroviral method. We failed to generate iPS cells from patients with Fanconi Anemia and reticular dysgenesis without gene collection at the stage of skin fibroblasts. We have confirmed recapitulation of phenotypes with several disease-specific iPS cells including CINCA syndrome, reticular dysgenesis and Chediak-Higashi syndrome.
期刊论文(126)
专著(0)
科研奖励(0)
会议论文
Outcome of Immunousuppressive therapy in children with fulminant aplastic anemia.
暴发性再生障碍性贫血儿童免疫抑制治疗的结果。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kiyoshi Sato, Ji-Won Lee, Kei Sakamoto, Tadahiro Iimura, Kou Kayamori, Hisataka Yasuda, Masanobu Shindoh, Masako Ito, Ken Omura, Akira Yamaguchi, 大橋俊夫, 阿部裕輔, Yagasaki H]
通讯作者: Yagasaki H
iPS細胞と遺伝性疾患
iPS细胞与遗传疾病
DOI: --
发表时间: 2010
期刊: 日本医師会雑誌
影响因子: --
作者: [Kubo A, Nagao K, Yokouchi M, Yoshida K, Sasaki H, Amagai M, Kobayashi K, 中畑龍俊]
通讯作者: 中畑龍俊
Langhans型巨細胞の形成にはCD40-CD40Lシグナルが必須である
CD40-CD40L 信号对于郎罕斯型巨细胞的形成至关重要
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [酒井秀政, 岡藤郁夫, 西小森隆太, 阿部純也, 八角高裕, 中畑龍俊, 平家俊男]
通讯作者: 平家俊男
小児疾患におけるiPS細胞の応用
iPS细胞在儿科疾病中的应用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N, 中畑龍俊]
通讯作者: 中畑龍俊
共 92 条
    Hematopoietic stem cell potential is propagated by human pluripotent stem cell-derived endothelial stroma
    • 批准号:
      24659496
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      NAKAHATA Tatsutoshi
    • 依托单位:
    Analysis of proliferation and differentiation of human embryonic stem cells and research for clinical application
    • 批准号:
      19109006
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $69.89万
    • 财政年份:
      2007
    • 负责人:
      NAKAHATA Tatsutoshi
    • 依托单位:
    molecular cloning of self-renewal factor for hematopoietic stem cells and its clinical application
    • 批准号:
      11357008
    • 项目类别:
      Grant-in-Aid for Scientific Research (A).
    • 资助金额:
      $22.4万
    • 财政年份:
      1999
    • 负责人:
      NAKAHATA Tatsutoshi
    • 依托单位:
    Studies of differentiation mechanisms of hematopoietic stem cells using cytokine-receptor transgenic mice
    海外基金