Development of new strategies to overcome glioblastoma invasiveness and drug-resistance using a glioma stem cell model

本研究的目的是确定恶性胶质瘤高侵袭性和侵袭性的分子基础，以开发新的治疗策略。使用我们的同基因小鼠胶质母细胞瘤模型，我们(1)建立了一种实时监测胶质瘤细胞对正常脑的侵袭的方法，并确定了主要的侵袭模式；(2)表明抑制胶质瘤细胞的间质特性有效地降低了侵袭能力，并确定了潜在的靶向药物。此外，我们还揭示了肿瘤细胞对内皮细胞的共选择和侵袭性COM的形成。(3)分析了在重复辐射中获得辐射抵抗的机制，并确定了其关键调节因素之一。

The goal of this study was to identify the molecular basis of the high invasiveness and aggressiveness of malignant gliomas in order to develop novel therapeutic strategies. Using our syngeneic murine model of glioblastoma, we(1) established an assay for the real-time monitoring of glioma cell invasion into the normal brain and identified the main invasion patterns;(2) showed that inhibition of mesenchymal characteristics of glioma cells effectively reduces invasion and identified potential targeting agents. Furthermore, we uncovered the co-option of endothelial cells by tumor cells and the formation of invasion com(3) analyzed the mechanism of aquired radioresistance during repeated radiation and identified one of its key regulators.