The technological development of bioengineered regenerated tooth, based on the mechanism of development

基于发育机制的生物工程再生牙技术进展

• 批准号: 22249064
• 负责人: KUBOKI Takuo
• 金额: $ 29.87万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22249064/
• 关键词: 再生歯

In the dental field, the regeneration of complete tooth is ultimate goal. First, we examined whether fully functional bioengineered tooth could regenerate utilizing an organ germ method with the permanent tooth bud tissue of the post-natal canine, we succeeded in it, for the first time in the world. Next, in order to understand the mechanism of tooth development, we performed the screening and clarified that several Hox gene specifically expressed in the development of tooth.

在口腔医学领域，完整牙齿的再生是最终的目标。首先，我们研究了全功能生物工程牙齿是否可以利用器官胚法与出生后的狗的恒牙芽组织再生，我们成功地在世界上第一次。接下来，为了进一步了解牙齿发育的机制，我们进行了筛选，明确了几个Hox基因在牙齿发育中特异表达。

项目成果

Expression Pattern of Hox Genes During Mouse Tooth Development

小鼠牙齿发育过程中Hox基因的表达模式

• 发表时间: 2013
• 作者: Shinkawa S;Uchibe K;Ono M;Sonoyama W;Hara ES;Yoshioka Y;Ueda J;Asahara H;Kuboki T
• 通讯作者: Kuboki T

抜歯窩肉芽組織からの新規間葉系幹細胞の同定

拔牙槽肉芽组织中新型间充质干细胞的鉴定

• 发表时间: 2013
• 作者: 中島隆;大野充昭;園山亘;笈田育尚;Emilio S.Hara;前川賢治;窪木拓男
• 通讯作者: 窪木拓男

L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 Activity*

• DOI: 10.1074/jbc.m112.343194
• 发表时间: 2012-04
• 期刊: The Journal of Biological Chemistry
• 作者: S. Yamashita;S. Miyaki;Y. Kato;Shigetoshi Yokoyama;Tempei Sato;F. Barrionuevo;H. Akiyama;G. Scherer;S. Takada;H. Asahara

Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family

• DOI: 10.1007/s12079-012-0180-4
• 发表时间: 2013-03-01
• 期刊: JOURNAL OF CELL COMMUNICATION AND SIGNALING
• 影响因子: 4.1
• 作者: El Kader, Tarek Abd;Kubota, Satoshi;Takigawa, Masaharu
• 通讯作者: Takigawa, Masaharu

miRNA-720 regulates stem cell phenotype, proliferation and differentiation of dental pulp cells.

miRNA-720 调节牙髓细胞的干细胞表型、增殖和分化。

• 发表时间: 2013
• 作者: Hara ES;Ono M;Sonoyama W;Eguchi T;Pham HT;Calderwood SK;Kuboki T.
• 通讯作者: Kuboki T.