The technological development of bioengineered regenerated tooth, based on the mechanism of development

在口腔医学领域，完整牙齿的再生是最终的目标。首先，我们研究了全功能生物工程牙齿是否可以利用器官胚法与出生后的狗的恒牙芽组织再生，我们成功地在世界上第一次。接下来，为了进一步了解牙齿发育的机制，我们进行了筛选，明确了几个Hox基因在牙齿发育中特异表达。

In the dental field, the regeneration of complete tooth is ultimate goal. First, we examined whether fully functional bioengineered tooth could regenerate utilizing an organ germ method with the permanent tooth bud tissue of the post-natal canine, we succeeded in it, for the first time in the world. Next, in order to understand the mechanism of tooth development, we performed the screening and clarified that several Hox gene specifically expressed in the development of tooth.