The technological development of bioengineered regenerated tooth, based on the mechanism of development

在牙科领域，完整牙齿的再生是最终目标。首先，我们研究了利用器官胚胎法从出生后的犬永久牙芽组织中能否再生全功能生物工程牙齿，这在世界上是第一次成功的。接下来，为了了解牙齿发育的机制，我们进行了筛选，明确了几个HOX基因在牙齿发育中特异表达。

In the dental field, the regeneration of complete tooth is ultimate goal. First, we examined whether fully functional bioengineered tooth could regenerate utilizing an organ germ method with the permanent tooth bud tissue of the post-natal canine, we succeeded in it, for the first time in the world. Next, in order to understand the mechanism of tooth development, we performed the screening and clarified that several Hox gene specifically expressed in the development of tooth.