Development for radio frequency ablation supporting system appropriate to coagulation area of tumor by clarifying coagulation mechanism

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In order to provide the accuracy of radio frequency ablation (RFA) treatment we proposed a RFA supporting treatment system. We mainly focused on the problems of RFA treatment and proposed the solutions such as (1) clarify the mechanism of coagulation in RFA and (2) develop the temperature distribution simulator based coagulation condition. We employed both mechanical method and biology method to make analyze the coagulation condition and evaluate the experimental results. According to the in vitro experiments, we found that the viscoelasticity of tissue in RFA treatment was useful as the index of coagulation condition and modeled the temperature dependence of viscoelasticity. And we used both mechanical method and biology method to derive and evaluate the parameters of ablation condition, which determined the coagulation condition of tissue. We also validated the bio-heat transfer model in RFA and developed the temperature distribution numerical simulator for RFA.