Clinical test system utilizing near infrared fluorescence of nanotubes

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The aims of this project are to establish the immunoassay system using single-walled carbon nanotubes (CNTs) as a near infrared (NIR) fluorescence label and to make a new NIR fluorescence detection apparatus that is suitable for the clinical test uses.The most important issue to achieve our purpose was the preparation of complex of CNTs and IgG antibody. Many problems of this preparation which were mostly originated from the unique structures and properties of CNTs were solved, and, as a result, it became possible to make CNT-IgG stably. In addition, we have succeeded in making the palm-sized apparatus for the NIR fluorescence detection with sensitivity high enough to detect the CNTs fluorescence in the immunoassay. Our results will enable to develop new clinical test systems using CNTs as NIR fluorescence labels.