Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model

小动物模型中中和和非中和单克隆抗体预防 SARS-CoV-2 的机制

• 批准号: 458682471
• 负责人: Professor Dr. Klaus Überla
• 金额: --
• 依托单位: Virologisches Institut - Klinische und Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/458682471?language=en
• 关键词: Mechanisms; protection; SARS; CoV; neutralizing

Neutralizing monoclonal antibodies to SARS-CoV2 have been shown to reduce viral load after challenge of passively immunized animals. Since the mechanisms of protection have not been defined the project aims to determine whether Fc-effector mechanisms contribute to protection and whether neutralizing and non-neutralizing antibodies to the SARS-COV-2 spike protein can prevent in vivo the infection of the first cells by viruses from the inocculum.

经证明，针对 SARS-CoV2 的中和单克隆抗体可以减少被动免疫动物攻击后的病毒载量。由于保护机制尚未明确，该项目旨在确定 Fc 效应机制是否有助于保护，以及 SARS-COV-2 刺突蛋白的中和和非中和抗体是否可以在体内防止第一批细胞被接种物中的病毒感染。