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Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model

Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model
小动物模型中中和和非中和单克隆抗体预防 SARS-CoV-2 的机制
批准号:
458682471
负责人:
Professor Dr. Klaus Überla
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2021
资助国家:
德国
项目状态:
已结题
起止时间:
2020-12-31 至 2021-12-31

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中文摘要
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英文摘要
Neutralizing monoclonal antibodies to SARS-CoV2 have been shown to reduce viral load after challenge of passively immunized animals. Since the mechanisms of protection have not been defined the project aims to determine whether Fc-effector mechanisms contribute to protection and whether neutralizing and non-neutralizing antibodies to the SARS-COV-2 spike protein can prevent in vivo the infection of the first cells by viruses from the inocculum.
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Mechanism of enhancement of RNA packaging by Rev proteins of immunodeficiency viruses
Virale Determinanten der präferentiellen Integration lentiviraler Vektoren in transkriptionell-aktive Bereiche
Einfluss lentiviraler Gene auf die Differenzierung und Funktion von Dendritischen Zellen
国内基金
海外基金
加密/签名的密钥泄露保护机制研究
  • 批准号:
    60970111
  • 项目类别:
    面上项目
  • 资助金额:
    33.0万元
  • 批准年份:
    2009
  • 负责人:
    陈克非
  • 依托单位: