Multinuclear upgrade/extension for ultra highfield MRT

超高场 MRT 的多核升级/扩展

• 批准号: 458912084
• 金额: --
• 依托单位: Julius-Maximilians-Universität Würzburg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/458912084?language=en
• 关键词: Multinuclear; upgrade; extension; ultra; highfield

Imaging of molecular and cellular cardiovascular processes by X-nuclei magnetic resonance techniques is promising to become one of the most relevant applications of translational ultra-high field MRI. 19F MR tracers, which are ingested by macrophages, may quantify extend and time course of inflammation following myocardial infarction or during myocarditis. This should allow to obtain prognostic parameters and to evaluate immunomodulatory therapies with the final aim, to apply them to patients. Another application focuses on the differential quantification of free and bound fractions of sodium in the intra- and extracellular space of myocardium. These sodium fractions affect in a complex, in large parts not well understood, way remodelling of the extracellular matrix, which may be important for the development of heart failure. The relationship of these different sodium fractions, as well as the effect of interventions, e.g. by application of SGLT2 inhibitors, will be obtained for several disease-models /pathologies as myocardial infarction, various forms of cardiac hypertrophy, and diabetes. Characterization of myocardial energetics of ischemic, hypertrophic and dilative cardiomyopathy by 31P spectroscopy / imaging is another focus. In particular, the effect of new therapeutic strategies targeting mitochondria or the sarcomer in cardiomyopathies will be investigated. In advance of all these biomedical aims, sophisticated technical and methodical developments have to be accomplished. This refers to coil construction and validation as well as establishing of dedicated sequences. Combined 1H/X-nuclei coils are a prerequisite to obtain besides molecular/cellular also morphological and functional information. In 19F MRI multiple resonances of common fluorocarbon tracers are a challenge, which may be tackled by selective spectral excitation or fingerprinting techniques. Differential sodium MRI depends on ultrashort echo time sequences (UTE), which must be combined with special k-space trajectories (stack of spirals) which are robust against gradient artefacts. Essential for all technical and biomedical projects mentioned above is the implementation of a special hard-/ software upgrade/extension (multinuclear support). Without this, neither X-nuclei coils operate nor may sequences be developed. This upgrade/extension is applied in this proposal.

通过X-核磁共振技术对分子和细胞心血管过程进行成像有希望成为平移超高场MRI最相关的应用之一。被巨噬细胞摄取的19 F MR示踪剂可以量化心肌梗死后或心肌炎期间炎症的范围和时间过程。这将允许获得预后参数，并评估免疫调节治疗的最终目标，将其应用于患者。另一个应用程序集中在心肌的细胞内和细胞外空间的游离和结合分数的钠的差分定量。 这些钠组分以一种复杂的方式影响细胞外基质的重塑，其中很大一部分尚未得到很好的理解，这可能对心力衰竭的发展很重要。 这些不同钠组分之间的关系以及干预措施的影响，例如通过应用SGLT 2抑制剂，将获得几种疾病模型/病理学，如心肌梗死、各种形式的心脏肥大和糖尿病。通过31 P光谱/成像表征缺血性、肥厚性和扩张性心肌病的心肌能量学是另一个焦点。 特别是，将研究心肌病中靶向线粒体或肌角的新治疗策略的效果。 在所有这些生物医学目标之前，必须完成复杂的技术和方法的发展。这指的是弹簧圈的构造和验证以及专用序列的建立。组合的1H/X-核线圈是除了获得分子/细胞信息之外还获得形态和功能信息的先决条件。 在19 F MRI中，常见碳氟化合物示踪剂的多重共振是一个挑战，这可以通过选择性光谱激发或指纹技术来解决。差分钠MRI取决于超短回波时间序列（UTE），它必须与特殊的k空间轨迹（螺旋堆叠）相结合，这对梯度伪影是鲁棒的。 对上述所有技术和生物医学项目至关重要的是实施特别的硬件/软件升级/扩展（多核支持）。如果没有这个，X核线圈就无法工作，序列也无法开发。本次升级/扩展适用于本提案。