Catalytic Organic Synthetic Processes in Water: Zero-Emission Switching

水中催化有机合成过程：零排放转换

• 批准号: 11555243
• 负责人: UOZUMI Yasuhiro
• 金额: $ 7.23万
• 依托单位: Institute for Molecular Science (2000-2001)Nagoya City University (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11555243/
• 关键词: ansition metal catalysts; palladium-phosphine complexes; amphiphilic solid support; organic transformation in water; PS-PEG resin; palladium catalysis; PS-PEGレジン

Owing to increasing environmental concerns about harmful and resource-consuming solvent waste, the chemistry of organic transformations in water is presently undergoing very rapid growth. On the other hand, development of immobilized reagents has been attracting significant interest for their practical advantages. There is good reason to believe that immobilized catalysts exhibiting high catalytic activity in aqueous media offer a viable clean alternative to more traditional methods of accomplishing many organic reactions. We have examined design and preparation of amphiphilic resin-supported triarylphosphine-palladium complexes bound to a polyethylene glycol-polystyrenegraft copolymer (PEG-PS resin) which exhibit high catalytic activity in allylic substitution reactions of allyl acetates with various nucleophiles in aqueous media under mild reaction conditions. As a part of our efforts to develop the wide utility of these catalysts, the palladium-catalyzed cross-coupling reaction and palladium-catalyzed hydroxycarbonylation in water were also successfully examined.

由于对有害和资源消耗的溶剂废物的环境关注日益增加，水中有机转化的化学目前正在经历非常迅速的发展。另一方面，固定化试剂的发展因其实用的优点而引起了人们的极大兴趣。有充分的理由相信，固定化催化剂在水介质中表现出高催化活性，为完成许多有机反应的更传统的方法提供了一种可行的清洁替代方法。我们研究了聚乙二醇-聚苯乙烯接枝共聚物(聚乙二醇-聚苯乙烯接枝共聚物)两亲性树脂负载的三芳基膦-钯配合物的设计和制备，在温和的反应条件下，它在水介质中对乙酸烯丙酯与各种亲核试剂的烯丙基取代反应表现出很高的催化活性。作为开发这些催化剂广泛用途的努力的一部分，我们还成功地研究了钯催化的交叉偶联反应和钯催化的水中的羟甲基化反应。

项目成果

魚住 泰広: "Double Carbonylation of Aryl lodides with Primary Amines under Atmospheric Pressure Conditions Using Pd/PPh_3/DABCO/THF System"J. Org. Chem.. 66. 5272-7274 (2001)

Yasuhiro Uozumi：“在大气压条件下使用 Pd/PPh_3/DABCO/THF 系统进行芳基碘化物的双重羰基化”J Chem. 66. 5272-7274 (2001)

魚住 泰広: "Catalytic Asymmetric Allylic Alkylation in Water with a Recyclable Amphiphilic Resin-Supported P, N-Chelating Palladium Complex"J. Am. Chem. Soc.. 123. 2919-2920 (2001)

Yasuhiro Uozumi：“使用可回收的两亲性树脂支持的 P、N-螯合钯络合物在水中催化不对称烯丙基烷基化”J. Am. 123. 2919-2920 (2001)

魚住 泰広: "Green Catalysis : Hydroxycarbonylation of Aryl Halides in Water Catalyzed by Amphiphilic Resin-Supported Palladium-Phosphine Complexes"J. Org. Chem.. 64. 6921-6923 (1999)

Yasuhiro Uozumi：“绿色催化：两亲性树脂负载的钯-膦配合物催化水中芳基卤化物的羟基羰基化”J Chem. 64. 6921-6923 (1999)

Yasuhiro Uozumi: "Allylic Substitution in Water Catalyzed by Amphiphilic Resin-Supported Palladium-Phosphine Complexes"Tetrahedron. 55. 14341-14352 (1999)

Yasuhiro Uozumi：“两亲性树脂支持的钯-膦配合物催化水中的烯丙基取代”四面体。

魚住 泰広: "Allylic Substitution in Water Catalyzed by Amphiphilic Resin-Supported Palladium-Phosphine Comniexes"Tetrahedron. 55. 14341-14352 (1999)

Yasuhiro Uozumi：“两亲性树脂支持的钯-膦复合体催化水中的烯丙基取代”四面体 55。14341-14352 (1999)