Development of CdZnTe gamma camera for radioguided surgery

开发用于无线电引导手术的 CdZnTe 伽玛相机

• 批准号: 11557142
• 负责人: TSUCHIMOCHI Makoto
• 金额: $ 8.45万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11557142/
• 关键词: γcamera; γprobe; CdTe; semiconductor; radioguided surgery; RI detector; sentinel lymph node; RIGS

Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, gamma probes can only provide radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows the size, shape, and location of the target tissues to be visualized. The purpose of this study is to characterize the performance of the SSGC for radioguided surgery of metastatic lesions and for diagnosing other diseases amenable to the smaller-format associated with this prototype imaging system. Methods ＆ Design : The detector head was comprised of a 32 x 32 Cadmium Telluride semiconductor array and application-specific integrated circuit (ASIC) with a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mm x 166 mm x 65 mm. The effective visual field was 44.8 mm x 44.8 mm. Two spherical 5 mm diameter Tc-99 m radioactive sources having activities of 0.15 MBq and 100 MBq were used to simulate sentinel lymph nodes and injection site. The relative detectability of these foci was compared using the new detector and a conventional scintillation camera. Use of the prototype was also explored on patients in a variety of clinical applications. Results : The SSGC provided better spatial resolution on phantom studies than the conventional gamma camera control. Both foci could be visualized clearly by the SSGC using a 15-second acquisition time, whereas they could not be readily identified using the conventional system under comparable conditions. Preliminary clinical tests of the SSGC were found to be successful in imaging diseases in a variety of tissues including salivary and thyroid glands, temporomandibular joints, and sentinel lymph nodes. Conclusion : The SSGC has significant potential for use in diagnosing diseases and for facilitating subsequent radioguided surgery.

伽马探头已被用于黑色素瘤和乳腺癌的前哨淋巴结活检。然而，伽马探头只能提供基于检测到的放射性强度的放射性计数和可变音调音频输出。我们开发了一种小型半导体伽马相机(SSGC)，可以直观地显示目标组织的大小、形状和位置。这项研究的目的是描述SSGC在放射引导下的转移性病变手术和诊断其他适合于与该原型成像系统相关的较小格式的疾病的性能。方法与设计：探测器头由32×32碲化镉半导体阵列和带有钨准直器的专用集成电路(ASIC)组成。整个组件被包裹在一个152 mm x 166 mm x 65 mm的引线外壳中。有效视野为44.8 mm×44.8 mm。用两个直径为5 mm、活度分别为0.15mBq和100mBq的球形TC-99m放射源模拟前哨淋巴结和注射部位。使用新的探测器和传统的闪烁相机比较了这些焦点的相对可探测性。该原型还在患者的各种临床应用中进行了探索。结果：SSGC在体模研究中提供了比常规伽马相机对照更好的空间分辨率。SSGC可以使用15秒的采集时间清楚地显示这两个病灶，而在类似条件下使用传统系统不能很容易地识别它们。SSGC的初步临床测试被发现成功地对各种组织的疾病进行了成像，包括唾液和甲状腺、颞颌关节和前哨淋巴结。结论：SSGC在疾病诊断和辅助手术方面具有重要的应用潜力。

项目成果

Tsuchimochi M., Sakahara H., Hayama K., Shirahata T.: "Development of a nuclear imaging device for intraoperative use"Journal of Medical Imaging and Information. Vol.33 No.11. 1038-1046 (2001)

Tsuchimochi M.、Sakahara H.、Hayama K.、Shirahata T.：“术中使用核成像设备的开发”医学影像与信息杂志。

土持 眞: "術中核医学画像診断機器の開発"映像情報. 33・11. 1038-1046 (2001)

土持诚：“核心医学影像诊断设备的开发”视频信息33・1046（2001）。

M.TSUCHIMOCHI et al.: "Performance of a Small CdTe Gamma Camera for Radioguided Surgery"PENETRATING RADIATION SYSTEMS AND APPLICATIONS III. SPIE 4508. 74-87 (2001)

M.TSUCHIMOCHI 等人：“用于无线电引导手术的小型 CdTe 伽玛相机的性能”穿透辐射系统和应用 III。

M.TSUCHIMOCHI et al.: "Development of a New Small High Resolution Gamma Camera for Radioguided Surgery"European Journal of Nuclear Medicine. 27・8. 973 (2000)

M.TSUCHIMOCHI 等人：“用于无线电引导手术的新型小型高分辨率伽马相机的开发”欧洲核医学杂志 27・8 (2000)。

土持 眞: "RIガイド手術のための小型高分解能ガンマカメラ"日本放射線技術学会雑誌. 57・7. 751-758 (2001)

Makoto Tsuchimochi：“用于 RI 引导手术的紧凑型高分辨率伽马相机”日本放射线技术学会杂志 57・758（2001 年）。