MOLECULAR DESIGN OF BIOACTIVE HYBRID COMPLEXES

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Human activity has serious and adverse effects on the Earth's ecosystems. To keep the beautiful natural environment, chemists should play an important role in much respect. From this viewpoint, we have hold a great interest in green chemistry (=we call green earth chemistry) over the past years and studied the following topics on the basis of coordination chemistry. A set of 1,3-propanediamine derivatives connected to carbohydrates has been prepared. D-Glucose, D-mannose, D-galactose, D-xylose, D-ribose, and D-maltose are utilized as sugar molecules in this work. The diamine moiety was connected to the Cl carbon of the glycopyranose ring via an O-glycoside bond. All the anomeric configurations and sugar puckering conformations, except in the D-maltose derivative, were determined by X-ray crystallography of the diazido or dibromo precursors. This method has been used to synthesize a library of sugar-pendant diamines including an OH-protected derivative, and an N,N'-diisopropyl-substituted derivative. Acidty constants of these sugar-pendant diamines have been examined, as have the stability constants of these ligands with the divalent metal ions in solution. The effective antitumor cisplatin type complexes of these sugar-pendant dimaines were developed. Sugar-dependent photocytotoxic property of tetra- and octa-glycoconjugated tetraphenylporphyrin and fullarene derivatives has been examined. Effective phototoxic property of newly prepared these glycoconjugated compounds was observed. Functional modification of surface of gold electrodes by utilizing Fe and Ru clusters relevant to non-heme diiron Active Centers has been carried out.