DEVELOPMENT OF METAL COMPLEXES WITH PHYSIOLOGICAL RESPONSE FUNCTION

具有生理反应功能的金属配合物的开发

• 批准号: 05303008
• 负责人: YANO Shigenobu
• 金额: $ 3.84万
• 依托单位: NARA WOMEN'S UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05303008/
• 关键词: Bioactivity; Antifungal Activity; Hybrid Compound; Molecular Recognition; Intercalation; DNA; Active Oxygen; Photodynamic Therapy; 配糖錯体; 血糖値の制御; シッフ塩基; 有機無機複合体; 生物機能

Development of metal complexes with physiological response function is highly desirable in various fields. We have carried out the following investigations during this two years. Nickel(II)complex containing N-glycosides derived from D-glucosamine and ethylenediamine showed effective antifungal activity against pathogenic yeast, Candida Albicans. (YANO and KATO)Hydrogen bonding and metal coordination interactions can be used to force aromatic spacers to stack. (AOYAMA)The cell damage by the irradiation of laser light to zinc phthalocyanine incorporated cells were revealed to be caused by singlet oxygen. (OKURA)Artificial ligands were synthesized and it became becapossible to inhibit the activation or the DNA binding of NF-kB and HIV-EP1, kB site binding proteins. (OTSUKA)Self-assembled and higher ordered metal complexes in aqeous solution and in crystal were constructed by intermolecular stacing interactions. (ODANI) Insulin-like effect in terms of blood glucose normalization was inves … More tigated to find anti-diabetic drugs for insulin-dependent diabetes mellitus by vanadium-or selenium-containing complexes. (SAKURAI)Direct electron-transfer reactions of metalloproteins at functional electrodes and their applications have been discussed. (TANIGUCHI)The measurement of DNA-fiber ESR has revealed the binding structure of Cu(II)complexes of amino acids and peptides. (CHIKIRA)High levels of "catalytic stereocontrol based on molecular recognition" have been achieved in the Eu(III)-catalyzed aldol reactions. (NAKAI)Fe(III)TRAA(TPAA : tris(N-(2-pyridylmethy1)-2-aminoethy1)amine)showed high SOD activity not only in vitro but also in vivo. (NAGANO)The administration of Fe(III)-nta solution to rats produces renal cell carcinoma and induces severe tissue damage. (NISHIDA)Monoclonal antiboies to(1R,2R)-cyclohexanediamine platinum(II)-DNA adduct were obtained and characterized by ELISA method. (HIROSE). New cationic Schiff Base complexes were synthesized and the binding constants and modes with calf thymus DNA were investigated. (FUJII)The structures of zinc and mercury complexes including Cys-Pro-Leu-Cys as ligand were studied. (YAMAMURA) Less

开发具有生理反应功能的金属配合物在各个领域都是迫切需要的。在这两年中，我们进行了以下调查。由氨基葡萄糖和乙二胺衍生的n -糖苷组成的镍（II）配合物对白色念珠菌具有良好的抗真菌活性。（YANO and KATO）氢键和金属配位相互作用可以用来迫使芳香间隔物堆叠。（AOYAMA）激光照射对酞菁锌结合细胞的损伤是由单线态氧引起的。（OKURA）人工配体的合成使得抑制NF-kB和HIV-EP1、kB位点结合蛋白的激活或DNA结合成为可能。（OTSUKA）通过分子间稳定相互作用在水溶液和晶体中构建了自组装和高有序的金属配合物。（ODANI）在血糖正常化方面研究了胰岛素样作用…更多的研究是通过含钒或含硒复合物寻找胰岛素依赖型糖尿病的降糖药。（SAKURAI）本文讨论了金属蛋白在功能电极上的直接电子转移反应及其应用。（TANIGUCHI） dna纤维ESR的测量揭示了氨基酸和肽的Cu（II）配合物的结合结构。高水平的“基于分子识别的催化立体控制”已经在Eu（III）催化的醛醇反应中实现。（NAKAI）Fe(III)TRAA（TPAA: tris(N-(2-pyridylmethy1)-2-aminoethy1)amine）在体外和体内均表现出较高的SOD活性。（NAGANO） Fe(III)-nta溶液对大鼠产生肾细胞癌并诱导严重的组织损伤。（NISHIDA）获得了(1R,2R)-环己二胺铂(II)-DNA加合物单克隆抗体，并通过ELISA法进行了鉴定。(HIROSE)。合成了新的阳离子席夫碱配合物，并研究了其与小牛胸腺DNA的结合常数和结合模式。（FUJII）研究了以Cys-Pro-Leu-Cys为配体的锌汞配合物的结构。(YAMAMURA)少

项目成果

Y.Sugihara: "The Structure of Diethy(3-pyridy1)borane" J.Chem.Soc., Chem.commun.1925-1926 (1994)

Y.Sugihara：“二乙基（3-吡啶1）硼烷的结构”J.Chem.Soc.，Chem.commun.1925-1926（1994）

T.Nakai: "[2,3] Witig Sigmatropic Rearrangement." Organic Reactions. 23. 105-109 (1994)

T.Nakai：“[2,3] Witig Sigmatropic 重排。”

大塚 雅巳: "Cleavage of Yeast tRNA^<Phe> with Ni(III)and Co(III)Complex of Bleomycin" Biochem.Biophys.Res.Commun.191. 1338-1346 (1993)

Masami Otsuka：“用博莱霉素的 Ni(III) 和 Co(III) 复合物裂解酵母 tRNA^<Phe>”Biochem.Biophys.Res.Commun.191（1993）。

西田 雄三: "High catalytic activity of trans-FeCl_2(cyclam)^+ for peroxidation of linolenic acid" Chem.Lett.411-414 (1993)

Yuzo Nishida：“反式 FeCl_2(cyclam)^+ 对亚麻酸过氧化的高催化活性”Chem.Lett.411-414 (1993)

Y.Funahashi: "Spectroscopic Evidence for the Redox Reaction between Copper(II)and a Pterin Cofactor Model・・・・" Chem.Lett.385-388 (1994)

Y.Funahashi：“铜 (II) 和蝶呤辅因子模型之间氧化还原反应的光谱证据……”Chem.Lett.385-388 (1994)