Network for the localization of membrane and secretory proteins in Bacillus srubtilis.

枯草芽孢杆菌和相关细菌具有生产高水平胞外酶的能力，它们已被用作工业中酶的生产者。为了分析蛋白质分泌机制产生这些酶的分子机制，以及蛋白质分泌与蛋白质在细胞膜中的定位之间可能存在的网络，我们研究了以下内容：1)将分泌前蛋白靶向到细胞膜的信号识别颗粒（SRP）各组分的蛋白质组成和功能2)SRP受体FtsY与Ffh的相互作用；综合分析膜蛋白及其与蛋白质分泌机制的关系，将蛋白质定位到细胞膜上

Bacillus subtilis and related bacteria has the ability to produce high levels of extracellular enzymes and they have been used as producers of the enzymes in industries. To analyze the molecular mechanism for the protein secretion machinery to produce the enzymes and a possible network between the protein secretion and the localization of proteins in the cell membrane, we have studied as follows1)Protein composition and function of each component of signal recognition particle (SRP) that targets the presecretory proteins to the cell membrane2)Interaction between FtsY, a receptor of SRP, and Ffh, a component of SRP3)Comprehensive analysis of membrane proteins and their relation to the protein secretory machinery to localize the proteins into the cell membrane