Autonomic nervous functions in fetal type Minamata disease patients : assessment of heart rate variability.

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In order to assess the cardiovascular autonomic nervous functions patients with fetal type Minamata disease (FMD), we investigated blood pressure (BP), and conducted time and frequency domain analysis of heart rate variability (HRV). Subjects were 9 patients in Meisuien recognized as FMD, and 13 healthy age matched control subjects. Time domain analysis and frequency domain analysis by fast Fourier transformation (FFT) were conducted. In the time domain analysis, the mean RR of the FMD group was significantly lower than that of the control group. Neither SD RR nor CV showed significant differences between the two groups, but both tended to be lower in the group was significantly lower than that of the control group. These findings suggest that parasympathetic nervous dysfunction might exist in FMD patients, who were exposed to high doses of methylmercury during the prenatal period.