Study of Vesicoureteral Reflux (VUR) in Children

儿童膀胱输尿管反流 (VUR) 的研究

• 批准号: 12470325
• 负责人: KOYANAGI Tomohiko
• 金额: $ 9.54万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470325/
• 关键词: Children; Vesico-ureteral reflux; Urodynamics; Voiding pressure; Unstable bladder; Urethral ring (Cobb's collar); TUI; 下部尿路症状; 膀胱尿管逆流(VUR); 男児; 先天性リング状尿道狭窄(Cobb'sカラー); 排尿圧; 腎瘢痕

1) Urodynamic study and renal scintigraphic evaluation were done on 14 boys with primary VUR. Their ages ranged 4 months to 10 years with an average 4.2 years. 8 were bilateral and 6 unilateral. Severity of VUR were grade III or less in 8 patients and grade IV or more in 6. Voiding pressure was apparently high of 82 cm H_2O in those (7 patients) older than 3 years old (group A) while it was 57 cm H_2O in 3 patients younger. Bladder instability was not found in group B while it was noted in 57 % of group A. There was no correlation among the renal scarring, voiding pressure and/or severity of VUR. High intravesical pressure, be it during voiding or with unstable contraction, appears to be relevant in the genesis and aggravation of VUR.2) Relevance of bulbar urethral (ring-like) stricture (i.e. Cobb's collar) to VUR was studied. In the past 5 years 74 boys (average age 5 years old) were noted to have the lesion. 54 per cent presented with febrile urinary infection and noted to have VUR. Urinary incontinence (diurnal and/or enuresis) and hematuria were also noted. Bulbar indentation was the roentgenographic feature, while all were confirmed endoscopically with infant cystourethroscope. Bladder instability was noted in 89 per cent. Transurethral incision (TUI) was effective in controlling presenting illnesses, VUR and instability over 93 per cent. In evaluating VUR in young boys the presence of congenital urethral stricture (Cobb's collar) is to be reminded.

1）对14名主要VUR男孩进行了尿动力学研究和肾闪烁显像评估。他们的年龄范围为4个月至10年，平均4.2岁。 8个是双侧和6个单侧。在8例患者中，VUR的严重程度为III级或更低，IV级或6级或6级。在3岁以上（A组）（A组）的那些（7例）（7例）中，空隙压力显然为82 cm H_2O，而在3名患者中为57 cm H_2O。在B组中未发现膀胱不稳定。在vur的起源和加剧中，无论是在空隙还是在收缩过程中，无论是在空隙还是不稳定的收缩。在过去的5年中，有74名男孩（平均5岁）有病变。 54％出现了发热的尿感染，并注意到了VUR。还注意到尿失禁（昼夜和/或遗传）和血尿。鳞茎凹痕是roent术的特征，而在婴儿膀胱囊肿术中所有这些都经过内窥镜检查。膀胱不稳定在89％中。经尿道切口（TUI）可有效控制93％以上的疾病，VUR和不稳定。在评估年轻男孩的VUR时，要提醒先天性尿道狭窄（Cobb的衣领）的存在。

项目成果

柿崎秀宏 他: "先端医療シリーズ7・泌尿器科 診断と治療の再前線 第1版"先端医療技術研究所、東京. 205-215 (2000)

Hidehiro Kakizaki 等人：“高级医学系列 7：泌尿学：诊断和治疗的前线，第 1 版”高级医疗技术研究所，东京 205-215 (2000)。

飴田 要, 他: "特集:ウロダイナミクスの発展-ビデオウロダイナミクス(2)小児"排尿障害プラクティス. 8(1). 13-19 (2000)

Kaname Ameda 等人：“专题：尿动力学的发展 - 视频尿动力学 (2) 儿科” 泌尿系统疾病实践。

柿崎 秀宏, 他: "Annual Review 腎臓 2001"IX 小児科領域 3.VURの内視鏡治療の現況. 201-206 (2001)

Hidehiro Kakizaki 等：“Annual Review Kidney 2001” IX Pediatrics 3.VUR 内镜治疗的现状 201-206 (2001)。

柿崎 秀宏, 他: "-小児泌尿器科学の最近の話題-機能的排尿障害"臨床泌尿器科. 54(12). 927-933 (2000)

Hidehiro Kakizaki 等人：“儿科泌尿学最新主题 - 功能性泌尿疾病”临床泌尿学 54(12) 927-933 (2000)。

Katsuya Nonomura, et al.: "Impact of congenital narrowing of the bulbar urethra(Cobb's Collar) and its transurethral incision in children"Year Book of Urology. 323-324 (2000)

Katsuya Nonomura 等人：“先天性尿道球部狭窄（Cobbs Collar）及其经尿道切口对儿童的影响”《泌尿外科年鉴》。