The basic and clinical study of effects of preoperative chemotherapy for the purpose of organ preservation surgery on oral squamous cell carcinoma
口腔鳞癌器官保留手术术前化疗效果的基础与临床研究
基本信息
- 批准号:12470444
- 负责人:
- 金额:$ 9.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To elucidate the clinical significance of effects of preoperative chemotherapy on cell kinetics, we examined the changes in mean DNA content and mitotic index (MI) in oral squamous cell carcinoma, and attempted to correlate them with patients' survival rates. Nuclear DNA content and the MI in 118 specimens from patients before and after chemotherapy were measured using a cell image analyzer. It was suggested that image analysis of nuclear DNA content in combination with MI is useful for assessment of the effects of preoperative chemotherapy on cancer cell kinetics. This type of analysis may serve as a diagnostic aid for predicting patients' survival and selecting the suitable adjuvant therapy for individual patients with oral squamous cell carcinoma.One hundred twenty-two specimens from patients with oral squamous cell carcinoma were investigated by staining with a polyclonal antibody against pRb2/p130. pRb2/p130 expression was found to be correlated significantly with clinical stage, cervical lymph node metastasis, and tumor differentiation. Expression of pRb2/p130 may be a good prognostic indicator in patients with oral squamous cell carcinoma.
为了阐明术前化疗对细胞动力学影响的临床意义,我们检测了口腔鳞状细胞癌中平均DNA含量和有丝分裂指数(MI)的变化,并试图将其与患者的生存率相关联。应用细胞图像分析仪测定了118例化疗前后患者的细胞核DNA含量和MI。结果表明,核DNA含量的图像分析结合MI是有用的术前化疗对癌细胞动力学的影响进行评估。这种类型的分析可以作为一个诊断援助,预测患者的生存和选择合适的辅助治疗,为个别口腔鳞状细胞癌pRb 2/p130的多克隆抗体染色122例口腔鳞状细胞癌患者进行了研究。pRb 2/p130的表达与临床分期、颈淋巴结转移及肿瘤分化程度有关。pRb 2/p130的表达可能是口腔鳞癌患者的一个良好的预后指标。
项目成果
期刊论文数量(58)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
木戸幸恵, 他: "口腔扁平上皮癌の治療期間別の予後因子の解析"日本口腔外科学会雑誌. 47(6). 331-340 (2001)
Yukie Kido等人:“口腔鳞状细胞癌治疗周期的预后因素分析”日本口腔颌面外科学会杂志47(6)(2001)。
- DOI:
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- 影响因子:0
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- 通讯作者:
Kubota, H., Noguchi, M., Takemura, K., Miyazaki, A., Suyama, T., Kido, Y., Kohama, G.: "A study of surgical management and prognostic factors for survival in patients with carcinoma of the lower alveolus and gingival"J Jpn Soc Oral Tumor. 13. 9-16 (2001)
Kubota, H.、Noguchi, M.、Takemura, K.、Miyazaki, A.、Suyama, T.、Kido, Y.、Kohama, G.:“癌症患者的手术治疗和生存预后因素的研究
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- 影响因子:0
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Tanaka, N., Ogi, K., Odajima, T., Dehari, H., Yamada, S., Sonoda, T., Kohama, G.: "pRb2/p130 protein expression is correlated with clinicopathologic findings in patients with oral squamous cell carcinoma"Cancer. 92. 2117-2125 (2001)
Tanaka, N.、Ogi, K.、Odajima, T.、Dehari, H.、Yamada, S.、Sonoda, T.、Kohama, G.:“pRb2/p130 蛋白表达与口腔溃疡患者的临床病理结果相关
- DOI:
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- 影响因子:0
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小浜源郁.他: "口腔扁平上皮癌の臨床所見と病理組織所見に基づいた外科治療-481例の分析-"日本口腔腫瘍学会誌. 13. 33-41 (2001)
Minamotoka Obama 等:“基于口腔鳞状细胞癌临床和组织病理学结果的手术治疗 - 481 例分析 -”日本口腔肿瘤学会杂志 13. 33-41 (2001)。
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- 影响因子:0
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Noguchi M., et al.: "Conyrol of cell proliferation kinetics of tumor in neoadjuvant chemothrrapy for advanced oral squamous cell carcinoma and its prognostic implications"Int Clin Oncol. 7. 138-144 (2002)
Noguchi M.等人:“晚期口腔鳞状细胞癌新辅助化疗中肿瘤细胞增殖动力学的控制及其预后意义”Int Clin Oncol。
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