Research on optimal training frequency from the view point of hormones which control blood pressure

运动时血压升高，因为血液循环增加。超过一定限度的高血压可能导致心脏负荷过重，并可能破坏血管。但这种情况很少发生，因为控制血压的激素如心房利钠肽（ANP）、血管紧张素II对循环系统的调节是正确的。然而，这些激素或受体的减少可能使调节不稳定。没有足够的ANP的运动可能使循环系统失去控制和危险。因此，了解ANP等控制血压的激素在运动过程中如何减少，运动后如何恢复，从循环的角度来描述安全的训练频率是很重要的。此外，研究运动对这些激素受体的影响也很重要。得到了以下结果：长期运动训练使大鼠肾上腺ANP受体数量减少，肾脏第二信使积累能力减弱。急性运动降低ANP对醛固酮释放的抑制作用。这些变化有利于维持机体的水分含量。游泳3小时及恢复后大鼠右心房ANP含量有明显变化。恢复24小时后，ANP含量恢复到静息水平。

Blood pressure increases during exercise, because of increment of circulation. High blood pressure above a certain limit may cause over load on heart and may disrupt blood vessel. But this kind of incident seldom occurres, because blood pressure controlling hormones such as atrial natriuretic peptide (ANP), angiotensin II regulate circulation system properly. However, reduction of these hormones or receptors may make the regulation unstable. Exercise without enough quantity of ANP may make circulation system out of good control and dangerous. So, it is important to know how quantity of blood pressure controlling hormones such as ANP decreases during exercise and recovers after exercise to describe safe training frequency from the view point of circulation. Also, it is important to study effect of exercise on the receptors of these hormones. The following results were obtained. Number of rat adrenal ANP receptors decreased and ability of accumulation of the second messenger in kidney were blunted by long term exercise training. Acute exercise reduced inhibitory action of ANP on aldosterone release. These changes are in favor of maintaining water content of body. Significant change of ANP content was observed in right atrium of rat by three hours swimming and the recovery. After 24 hours of recovery, ANP content returned to the resting level.