Effect of training on the uretic and antiuretic action of hormones.

观察运动训练对利尿和抗利尿激素的影响。以Wistar雄性大鼠为研究对象。用跑步机训练大鼠。他们跑了10周。跑步速度为30m/min，持续时间为90min。训练结束后，摘除肾脏和肾上腺。进行心钠素受体结合实验、喹酸环化酶实验和醛固酮释放实验。用放射免疫试剂盒检测cGMP和醛固酮的含量。以下是结果1.训练组和对照组大鼠肾脏ANP受体数目无明显差异。结果：1.训练组大鼠肌肉组织中Quanyate环化酶活力明显升高。训练组大鼠肾上腺ANP受体数量增加。但鸟苷环化酶活力在两组间无明显差异。这些结果表明，运动训练增加了利尿和抗利尿作用，水和电解质的平衡更精确地受到训练效果的调节。

Effects of exercise-training on the uretic and antiuretic hormones were investigated. Wistar male rats were used for the study. Rats were trained with treadmill. They run 10 weeks. The running speed were 30 m/min and the duration was 90 min at last. Kidneys and adrenals were excised after the training period. Binding assay of ANP receptor, quanylate cyclase assay and aldosterone releasing experiment were done. Assay for the cGMP and aldosterone were done with radioimmunoassay kit. The followings are the results.1. The number of kidney ANP receptors were not different between the trained rats and the control rat. But the quanylate cyclase activity was increased in the trained group.2. The number of adrenal ANP receptors were nincreased in the trained group. But the guanylate cyclase activity was comparable between the two groups.3. Aldosterone release was increased by the training.These results suggest that exercise-training increase both uretic and antiuretic action, and that water and electrolyte balance is more precisely regulated by the effect of the training.