Molecular mechanisms of the stripe pattern formation in zebrafish

(1)分离出斑马鱼hagoromo基因突变，该突变导致斑马鱼皮肤上出现异常条纹。(2)我们发现斑马鱼hagoromo基因编码一种新的F-box/WD40重复蛋白，与小鼠Dactylin基因同源。(3)我们发现hagoromo基因表达的微小改变导致突变表型。(4)建立了鱼皮上条纹图案的数学模型。(5)我们证明了方程参数的微小变化可以改变条纹模式。(6)我们发现hagoromo F-box/WD40蛋白是scf -泛素连接酶复合物的一个组成部分。

(1) We have isolated the zebrafish hagoromo mutations which caused abnormal stripe pattern on the skin.(2) We showed the zebrafish hagoromo gene, encoding a novel F-box/WD40 repeat-protein, is an ortholog of the mouse Dactylin gene.(3) We showed a small alteration in the hagoromo gene expression caused the mutant phenotype.(4) We established a mathematical model showing the stripe pattern on the fish skin.(5) We showed that a small change in a parameter of the equation can change the stripe pattern.(6) We showed that the hagoromo F-box/WD40 protein is a component of the SCF-ubiquitin ligase complex.