Construction of safety gude system for Operation by magnetic particles

磁粉作业安全引导系统的构建

• 批准号: 12480262
• 负责人: TANAKA Saburo
• 金额: $ 5.89万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12480262/
• 关键词: SQUID; Lymph Node; Particles; ELISA; Immunoassay; 磁気センサ; DNA; 抗原抗体反応; 磁性微粒子; センチネルリンパ節; がん; ラジオガイド; 乳がん

The performance of a lymph node detection system used with an ultra-small superparamagnetic iron oxide and a high-Tc SQUID was investigated. This system is applicable for sentinel lymph node biopsy which is a newly developed surgical technology. The sentinel node biopsy is a kind of examination to investigate whether the sentinel node, which initially receives malignant cells from a breast carcinoma is disease-free or not. If the sentinel node is free of disease, you can leave the rest of the lymph-nodes because of no concern for progression. Conventionally, a radio isotope was used to identify the sentinel lymph node. We propose the use of radio exposure-safe ultra small ion oxide particles such as a magnetic resonance imagine (MRI) contrast agent.After giving a shot of a MRI contrast agent to an arm of an anesthetic rat, a sentinel lymph node was extracted from the rat. Then the lymph node was measured by the SQUID system. We could successfully measure the magnetic signal from the lymph node. Although the real detection of the location of the lymph node in vivo was not performed yet, this result was good enough to apply the technology for the real detection.

研究了与超小型超顺磁性氧化铁和高 Tc SQUID 一起使用的淋巴结检测系统的性能。该系统适用于前哨淋巴结活检，这是一项新开发的外科技术。前哨淋巴结活检是检查最初接收乳腺癌恶性细胞的前哨淋巴结是否无病的检查。如果前哨淋巴结没有疾病，您可以保留其余淋巴结，因为无需担心病情进展。传统上，放射性同位素用于识别前哨淋巴结。我们建议使用辐射安全的超小离子氧化物颗粒，例如磁共振成像 (MRI) 造影剂。在向麻醉大鼠的手臂注射 MRI 造影剂后，从大鼠中提取前哨淋巴结。然后通过SQUID系统测量淋巴结。我们可以成功测量来自淋巴结的磁信号。虽然目前还没有对体内淋巴结的位置进行真正的检测，但这个结果足以将该技术应用于实际检测。

项目成果

S.Tanaka他: "Application of High Tc SQUID Magnetometer for Sentinel-Lymph Node Biopsy"IEEE Transactions on Applied Superconductivity. 11. 665-668 (2001)

S. Tanaka 等人：“用于前哨淋巴结活检的高温 SQUID 磁力计”IEEE 应用超导汇刊 11. 665-668 (2001)。

Saburo Tanaka, Hajime Ota Yoichi Kondo, Yukiko Matsuzawa, Yasuhiro Tamaki, and Shinzaburo Noguchi: "Sentinel Lymph Node Biopsy by a High Tc SQUID"Singapore Journal of Physics. 18. 17-22 (2002)

Saburo Tanaka、Hajime Ota Yoichi Kondo、Yukiko Matsuzawa、Yasuhiro Tamaki 和 Shinzaburo Noguchi：“利用高 Tc SQUID 进行前哨淋巴结活检”新加坡物理学杂志。

Saburo Tanaka 他: "Position Determine System for Lymph Node relating Breast Cancer using a High Tc SQUID"Physica C. 368. 32-36 (2002)

Saburo Tanaka 等：“使用高 Tc SQUID 的乳腺癌相关淋巴结定位系统”Physica C. 368. 32-36 (2002)

Saburo他: "Sentinel Lymph Node Biopsy by a High Tc SQUID"Singapore Journal of Physics. 18. 17-22 (2002)

Saburo 等人：“利用高 Tc SQUID 进行前哨淋巴结活检”《新加坡物理学杂志》18. 17-22 (2002)。

Saburo Tanaka, Hajime Ota, Yoichi Kondo, Yasuhiro Tamaki, Shinzaburo Noguchi and Masakatsu Hasegawa: "Position Determine System for Lymph Node relating Breast Cancer using a High Tc SQUID"Physica C. 368. 32-36 (2002)

Saburo Tanaka、Hajime Ota、Yoichi Kondo、Yasuhiro Tamaki、Shinzaburo Noguchi 和 Masakatsu Hasekawa：“使用高 Tc SQUID 的乳腺癌相关淋巴结的位置确定系统”Physica C. 368. 32-36 (2002)