Construction of safety gude system for Operation by magnetic particles

研究了使用超小超顺磁性氧化铁和高T_c鱿鱼的淋巴结检测系统的性能。该系统适用于前哨淋巴结活检这一新兴的外科技术。前哨淋巴结活检是一种检查乳腺癌前哨淋巴结是否无瘤的检查方法。如果前哨淋巴结没有疾病，你可以离开其余的淋巴结，因为不担心进展。传统上，使用放射性同位素来识别前哨淋巴结。我们建议使用放射暴露安全的超小离子氧化物颗粒，如磁共振成像(MRI)造影剂。在给麻醉大鼠的手臂注射MRI造影剂后，从大鼠的手臂上提取前哨淋巴结。然后用SQUID系统测量淋巴结的大小。我们可以成功地测量到来自淋巴结的磁信号。虽然还没有进行活体淋巴结位置的真实检测，但这一结果已经足够好地将该技术应用于真实检测。

The performance of a lymph node detection system used with an ultra-small superparamagnetic iron oxide and a high-Tc SQUID was investigated. This system is applicable for sentinel lymph node biopsy which is a newly developed surgical technology. The sentinel node biopsy is a kind of examination to investigate whether the sentinel node, which initially receives malignant cells from a breast carcinoma is disease-free or not. If the sentinel node is free of disease, you can leave the rest of the lymph-nodes because of no concern for progression. Conventionally, a radio isotope was used to identify the sentinel lymph node. We propose the use of radio exposure-safe ultra small ion oxide particles such as a magnetic resonance imagine (MRI) contrast agent.After giving a shot of a MRI contrast agent to an arm of an anesthetic rat, a sentinel lymph node was extracted from the rat. Then the lymph node was measured by the SQUID system. We could successfully measure the magnetic signal from the lymph node. Although the real detection of the location of the lymph node in vivo was not performed yet, this result was good enough to apply the technology for the real detection.