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Iodine laser development which oscillates with singlet delta oxygen produced by electric discharge, and its application for biological tissue fusion

利用放电产生的单线态δ氧振荡的碘激光的开发及其在生物组织融合中的应用

基本信息

批准号：
12555019
负责人：
FUJII Hiroo
金额：
$ 7.17万
依托单位：
Anan College of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

The Discharge Oxygen-Iodine Laser (DOIL) has been developed for the application of airborne laser system in Europe and the U.S. Especially, CU-Aerospace Co. in the US, who is our biggest competitor, is doing DOIL research very actively under a budget of US Air Force. After having detected the light amplification of DOIL emission first in the world in 2000, we have been trying to achieve mW power out-put by improving the system till the end of May 2003. But not only us but foreign teams can clear this target. Fruitful results, which obtained through this 3 years research term, are that 3 items, i.e.; increasing yield, iodine dissociation and laser gas cooling, are picked up for the mW power out-put, and feasible targets and the design data are established for each item. Fortunately, we are successful in getting a new budget for the DOIL research and doing big efforts for achieving oscillation on 2004.Concerning laser application for biological tissue fusion, welding tests of the main artery at a rat stomach were carried out using YAG laser beam which has a similar wavelength of DOIL. From the tissue scholarly view at fused position, it can be said that the abnormal reaction by foreign substance was hardly accepted, the fused tissue was recovered earlier by the laser than by the thread, and the constriction condition which appeared at early stage was soon disappeared. In order to suppress the aneurysm generation which tend to appear in this method, the fusion position was reinforced by covering artery with muscles film. As the results, the aneurysm completely disappeared and complications, such as denaturation or necrosis of fused tissue, were not observed for long-term. We conclude that the laser fusion on artery is an excellent method with the muscles film reinforcement.

放电氧碘激光器（DOIL）是欧洲和美国为机载激光系统应用而开发的。特别是我们最大的竞争对手美国CU-Aerospace公司在美国空军的预算下正在非常积极地进行DOIL研究。自2000年在世界上首次检测到DOIL发射的光放大后，直到2003年5月底，我们一直试图通过改进系统来实现mW功率输出。但不仅我们，国外团队也可以实现这一目标。通过这三年的研究，取得的丰硕成果有以下三项：提高产量、碘解离和激光气体冷却，针对毫瓦功率输出选取了可行的目标和每个项目的设计数据。幸运的是，我们成功地为DOIL研究获得了新的预算，并为实现2004年的振荡做出了巨大的努力。关于激光在生物组织融合中的应用，利用与DOIL波长相似的YAG激光束进行了大鼠胃主动脉的焊接试验。从融合部位的组织学观点来看，可以说很难接受异物引起的异常反应，激光比线材更早恢复融合组织，早期出现的收缩情况也很快消失。为了抑制该方法中容易出现的动脉瘤的产生，通过用肌肉膜覆盖动脉来加固融合位置。结果，动脉瘤完全消失，长期未观察到融合组织变性或坏死等并发症。我们得出的结论是，动脉激光融合是一种很好的肌肉膜加固方法。