Development of Bio-implant materials by Plasma-Spray Coating of Apatite and Their Evaluation

磷灰石等离子喷涂生物植入材料的研制及其评价

• 批准号: 12555203
• 负责人: OKUYAMA Masaru
• 金额: $ 3.71万
• 依托单位: Oyama National College of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12555203/
• 关键词: implant material; plasma spray; apatite coating; Thermal-diffusion treatment; チタン; ヒドロキシアパタイト; 拡散浸透処理; 生体インプラント材料; プラズマ溶射; 多孔質ヒドロキシアパタイト; コーテイング膜; 非結晶質リン酸カルシウム

In order to fabricate substitute artificial bone materials, the author tried plasma-coating of hydroapatite layer on metallic materials. However, the plasma-sprayed layers are so porous that body liquid penetrates to the substrates and attacks them. Moreover, because of extremely high temperature of ca.2,000℃, hydroapatite layer may easily decomposes and lose contact to the substrates. The author solved these problems and developed the plasma-sprayed hydroapatite coating materials. (1)The reaction of H3PO4 and Ca(OH)2 could not give hydroapatile but aging and heat-treatment promoted change into hydroapatite. (2)Plasma-spraying of, hydroapatite formed the coating layer without hydroapatite. However, controlling of the powder radius improved formation of hydroapatite. (3)Plasma-sprayed hydroapatite was amorphous, but crystallized by 3 hour and 800℃ heat-treatment. (4)Corrosion test of the hydroapatite-coated pure titanium, commercial Ti rod and SUS316 stainless steel was performed in 3.5%NaCl solution. Only the pure titanium was improved by hydroapatite coating. This is probably because joint between the hydroapatite layer and the substrate was tight. It was also found that the heat diffusion treatment improved their jointing.

为了制备替代性人工骨材料，作者尝试在金属材料表面等离子体涂覆羟基磷灰石层。然而，等离子体喷涂层是如此多孔，以至于体液渗透到基底并攻击它们。此外，由于约2，000 ℃的极高温度，羟基磷灰石层可能容易分解并失去与基底的接触。作者解决了这些问题，研制了等离子喷涂羟基磷灰石涂层材料。（1）H_3PO_4与Ca（OH）_2反应不能生成羟基磷灰石，但老化和热处理促进了羟基磷灰石的生成。（2）羟基磷灰石的等离子喷涂形成不含羟基磷灰石的涂层。然而，控制粉末半径改善了羟基磷灰石的形成。（3）等离子喷涂的羟基磷灰石为非晶态，经3h和800℃热处理后晶化。（4）在3.5%NaCl溶液中对水磷灰石涂层纯钛、市售钛棒和SUS316不锈钢进行了腐蚀试验。羟基磷灰石涂层仅对纯钛有改善作用。这可能是因为氢磷灰石层和基底之间的结合紧密。热扩散处理改善了它们的连接性。

项目成果

池葉博明: "プラズマ溶射ハイドロキシアパタイト被覆材に関する研究(II)"2001年電気化学秋季大会講演要旨集. 51 (2001)

Hiroaki Ikeba：“等离子喷涂羟基磷灰石涂层材料的研究（II）”2001年电化学秋季会议摘要51（2001）。

S. Take: "Preparation of Plasma Spray Hydroxy Apatite Coating (I)"J.Technology &Education. (submitting).

S.摘：《等离子喷涂羟基磷灰石涂层的制备（一）》J.Technology

武 成祥: "プラズマ溶射ハイドロアパタイト被覆材の特性に関する研究(II)"電気化学技術教育論文誌. (投稿中).

武重义：《等离子喷涂氢磷灰石涂层材料特性研究（二）》《电化学技术教育》杂志（正在投稿）。

Seisho TAKE: "Thermal Stability of Hydroapatite for Plasma Spray Coating"J.Technology &Education (Electrochem.Soc.Japan). 9, No.1. 81-86 (2000)

Seisho TAKE：“等离子喷涂用氢磷灰石的热稳定性”J.Technology

S.Take: "Preparation of Bio-compatible Plasma Spray Hydroxyapatite Coating"Proc. Sympo. on Marine Corrosion (Tokyo). 187-191 (2002)

S.Take：“生物相容性等离子喷涂羟基磷灰石涂层的制备”Proc。