DEVELOPMENT OF DISINTEGRATION AND CONTROL TECHNIQUE OF MICROCAPSULES INCLUDING A GAS BUBBLE FOR DRUG DELIVERY SYSTEMS USING UNDERWATER SHOCK WAVE

最近，冲击波和冲击波技术正在兴起。适用于医疗和生物技术行业，特别是体外冲击波碎石术(ESWL)、骨科骨重建、药物基因治疗。冲击波是一种传播速度大于声速的大压力变化波，其特点是：(1)单波和间断波，上升频率大；(2)持续时间约为微秒量级；(3)单位时间内能量传递大。利用这些特性，医学和工业需要新的技术和技术，但细胞崩解的基本机理还没有得到阐明。本研究的目的是研究这一机制，并将冲击波技术应用于生物加工工业和医学领域的细胞崩解。在我们的课题组中，利用冲击波和气泡进行细胞崩解的研究，以及利用这些技术开发新的生物过程和药物输送系统(DDS)，都是本课题组的主要工作之一。本课题组的主要工作如下：(1)利用冲击波和气泡对细胞进行解体；(2)利用冲击波和气泡对细胞进行解体；(2)利用激波和气泡对细胞进行解体；(2)利用激波和气泡对细胞进行解体，并开发新的生物过程和药物递送系统(…更多的是愤怒。本研究项目与德国埃尔兰根大学流体力学研究所合作，对以下三个问题进行了研究：(1)基于湍流剪切力(雷诺剪应力)的胶囊崩解；(2)基于冲击波的胶囊崩解和细胞变形过程数学模型的建立；(3)用于药物输送系统(DDS)的含气泡微胶囊的冲击波崩解，研究结果为：(1)湍流剪切流中细胞整合的剪应力阈值为1200~1400Pa.(2)对球壳-水相互作用的数学模型进行了修正，研究了超声和冲击波对水中单个细胞和两个细胞的变形和破坏。(3)利用任意拉格朗日-欧拉(ALE)计算方法分析了包括气泡在内的胶囊在超声和冲击波作用下的变形过程，发现内部气泡的不对称性和微喷对微胶囊的损伤有很大的影响。利用这些结果，可以得到以下结论微胶囊的崩解速率今后应由冲击波来控制。较少

Recently shock waves and shock wave technology are. applied to medical and biotechnological industries, especially extracorporeal shock wave lithotripsy (ESWL), bone reconstruction for orthpaedic, gene therapy with drug. Shock wave is large pressure change wave whose propagating velocity is larger than sound speed, and its features are (1)single and discontinues wave with large rising frequency, (2)duration time is about micro second order, (3) large energy transfer per unit time. Using these features, new technology and technique for medicine and industry are needed, but the fundamental mechanism for cell disintegration has not been, elucidated yeti In this study, our aim is to investigate this mechanism and apply the shock wave technology to disintegrate cell in the bioprocess industry and medical field.In our research group, the study about the cell disintegration using shock wave and a bubble, and also the new bioprocess and drug delivery systems (DDS) using these have being develo … More ped. In this research project, with cooperation of LSTM (Institute of Fluid Mechanics in German) in the University of Erlangen, Germany, which has been in pride of flow measurements and analysis, the following three topics are investigated, (1) Capsule disintegration by turbulent shear stress (Reynolds shear stress), (2)Capsule disintegration and establishment of mathematical cell deformation process model using shock wave, (3)Disintegration of microcapsules including a bubble using shock-wave for applying Drug Delivery Systems (DDS) And the results for these in this projects are(1)The threshold of shear stress for cell integration in turbulent shear flow is from 1200 to 1400 Pa, and this result are also applicable to the development of artificial organs, for instance blood pumps, and other medical flow device.(2)Modifying the mathematical model of spherical shell -water interactions, deformation and damage of a single and two cells in water by ultrasonic and shock wave with changing parameter (thickness of membrane and Young modulus) are investigated.(3)Deformation process of a capsule including, a bubble by ultrasonic and shock wave is analyzed using arbitrary Lagrangian-Eulerian (ALE) computational method, and it is found that asymmetry of internal bubble and micro jet have largeeffects on he damage of microcapsules.Using these results, the microcapsule disintegration rate should be controlled by shock wave in future. Less