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Research On MALT Lymphoma As a Model of Multistep Carcinogenesis

MALT 淋巴瘤作为多步癌变模型的研究

基本信息

批准号：
13470044
负责人：
AKAGI Tadaatsu
金额：
$ 7.81万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470044/
关键词：
Malignant lymphoma MALT lymphoma Multistep carcinogenesis Helicobacter pylori API2 MALT1 Heat shock protein 60 Adhesion molecules t(11;18)

项目摘要

1Eppression of adhesion molecules was investigated in MALT lymphomas of the G-I tract, ocular adnexa, and thyroid. α4s7 integrin and L-selectin were detected on low-grade MALT lymphoma cells and low-grade portions of high-grade MALT lymphoma, but not on high-grade portions of high-grade MALT lymphoma or diffuse large B-cell lymphomas. Most MALT lymphoma cases of the ocular adnexa were positive only for L-selectin. Neither was detected in the thyroid. MAdCAM-1, a ligand for α4s7 integrin, was expressed on the HEV in the inflammatory lesions and MALT lymphoma tissues of theG-I tract and thyroid, but not in the ocular adnexa or salivary gland.2.t(11;18)(API2/MALT1) in MALT lymphomas was investigated using FISH and RT-PCR. API2/MALT1 translocation was detected in a small portion of ocular adnexal and large intestinal MALT lymphomas and also rarely in diffuse large B-cell lymphomas and reactive lymphoreticular hyperplasia, but not in MALT lymphomas of the salivary gland and thyroid.3.Eradication of Helicobacter pylori induced complete remission in 88% of the patients with gastric MALT lymphoma, but not effective in the PI2/MALT1-positive cases.4.Clinicopathological and immunogenetic features of ocular adnexal lymphoproliferative disorders including MALT lymphomas were characterized.5. Clinicopathological features of multiple organ MALT lymphomas were characterized.6. Peripheral blood mononuclear cells in patients with MALT lymphoma showed increased expression of CD40 ligand and augmented production of IL4 by stimulation with cytokine or combined stimulation with HSP60. DNA microarray analysis indicated increased levels of HLA-DR and integrin mRNAs.

1研究黏附分子在胃肠道、眼附属器和甲状腺MALT淋巴瘤中的表达。α-4s7整合素和L-选择素在低度恶性MALT淋巴瘤细胞和高度恶性MALT淋巴瘤的低度恶性部位表达，而在高度恶性MALT淋巴瘤和弥漫性大B细胞淋巴瘤的高度恶性部位未检测到。大多数眼附件MALT淋巴瘤仅L-选择素阳性。在甲状腺中都没有检测到。α4s7整合素的配体MAdCAM-1在戊型肝炎病毒上表达，在G-I管炎性病变和MALT淋巴瘤组织中表达，但在眼附属器和唾液腺中不表达。API2/MALT1易位在少数眼附属器和大肠MALT淋巴瘤中检测到，在弥漫性大B细胞淋巴瘤和反应性淋巴网状增生中也很少见，但在涎腺和甲状腺的MALT淋巴瘤中未检测到API2/MALT1易位。3.根除幽门螺杆菌可使88%的胃MALT淋巴瘤患者完全缓解，但对PI2/MALT1阳性病例无效。4.包括MALT淋巴瘤在内的眼附属器淋巴增生性疾病的临床病理和免疫遗传学特征。总结多器官MALT淋巴瘤的临床病理特点。MALT淋巴瘤患者外周血单个核细胞经细胞因子刺激或HSP60联合刺激后，CD40配体表达增加，IL4产生增加。DNA微阵列分析显示，HLADR和整合素mRNAs水平升高。