Intervention-studies in weight control and skeletal muscle characteristics with food restriction and exercise

骨骼肌在能量代谢中起着重要的作用。因此，人们在大量的肥胖和糖尿病实验中研究了它的特性，以调查它们的贡献。根据主要通过横断面研究获得的临床和实验数据，纤维组成、毛细化、肌肉中的酶活性被认为参与了肥胖的可能发病机制。然而，在没有干预的情况下，所有这些横断面研究都不足以阐明这些假设。纵向研究提供了揭示骨骼肌特征与肥胖之间因果关系的可能性。我们根据精确的研究方案进行了研究。在这些研究中，骨骼肌对饮食诱导的体重控制的适应正在大鼠中进行研究。选择内脏脂肪作为分类标准。能量摄入没有显著差异。肌肉样本是在节食前后从同一块肌肉的同一部分采集的。结果可能有助于了解肥胖/瘦易感性。

Skeletal muscle plays an important role in energy metabolism. Therefore, its characteristics have been studied in numerous experiments on obesity as well as diabetes to investigate their contribution. According to the clinical and experimental data mainly obtained from cross-sectional studies, fiber composition, capillarization, enzyme activities in the muscle were considered to be involved in the possible pathogenesis of obesity. However, without interventions, all of these cross-sectional studies were inadequate to clarify any of these hypotheses. Longitudinal studies provided the possibility to reveal the causality between skeletal muscle characteristics and obesity. We carried out studies based on a precise study protocol. In these studies, skeletal muscle adaptation to diet-induced weight control is being investigated in rats. Visceral adipose was chosen to be the classificatory criterion. Energy intake is not significantly different. Muscle samples are collected from the same portion of the same muscle before and after the diet periods. Results which may contribute to the knowledge of obesity/lean-susceptibility are expected.