Intervention-studies in weight control and skeletal muscle characteristics with food restriction and exercise

骨骼肌在能量代谢中起着重要作用。因此，它的特性已经在许多关于肥胖症和糖尿病的实验中进行了研究，以调查它们的贡献。根据主要来自横断面研究的临床和实验数据，认为肌肉中的纤维组成、毛细血管化、酶活性参与了肥胖的可能发病机制。然而，如果没有干预措施，所有这些横断面研究都不足以澄清任何这些假设。纵向研究为揭示骨骼肌特性与肥胖之间的因果关系提供了可能性。我们根据精确的研究方案进行了研究。在这些研究中，正在大鼠中研究骨骼肌对饮食诱导的体重控制的适应性。选择内脏脂肪作为分类标准。能量摄入没有显著差异。在饮食期之前和之后从相同肌肉的相同部分收集肌肉样品。预期结果可能有助于了解肥胖/瘦易感性。

Skeletal muscle plays an important role in energy metabolism. Therefore, its characteristics have been studied in numerous experiments on obesity as well as diabetes to investigate their contribution. According to the clinical and experimental data mainly obtained from cross-sectional studies, fiber composition, capillarization, enzyme activities in the muscle were considered to be involved in the possible pathogenesis of obesity. However, without interventions, all of these cross-sectional studies were inadequate to clarify any of these hypotheses. Longitudinal studies provided the possibility to reveal the causality between skeletal muscle characteristics and obesity. We carried out studies based on a precise study protocol. In these studies, skeletal muscle adaptation to diet-induced weight control is being investigated in rats. Visceral adipose was chosen to be the classificatory criterion. Energy intake is not significantly different. Muscle samples are collected from the same portion of the same muscle before and after the diet periods. Results which may contribute to the knowledge of obesity/lean-susceptibility are expected.