Intervention-studies in weight control and skeletal muscle characteristics with food restriction and exercise

通过食物限制和运动控制体重和骨骼肌特征的干预研究

• 批准号: 13480009
• 负责人: KUMAGAI Shuzo
• 金额: $ 1.41万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13480009/
• 关键词: abdominal fat; food restriction; high fat diet; leptin; obesity; oxidative enzyme; skeletal muscle characteristics; weight reduction; 筋繊維組成; 速筋繊維優位ラット; インスリン感受性; インスリン抵抗性; エネルギー代謝; 酵素活性; 自発的活動量

Skeletal muscle plays an important role in energy metabolism. Therefore, its characteristics have been studied in numerous experiments on obesity as well as diabetes to investigate their contribution. According to the clinical and experimental data mainly obtained from cross-sectional studies, fiber composition, capillarization, enzyme activities in the muscle were considered to be involved in the possible pathogenesis of obesity. However, without interventions, all of these cross-sectional studies were inadequate to clarify any of these hypotheses. Longitudinal studies provided the possibility to reveal the causality between skeletal muscle characteristics and obesity. We carried out studies based on a precise study protocol. In these studies, skeletal muscle adaptation to diet-induced weight control is being investigated in rats. Visceral adipose was chosen to be the classificatory criterion. Energy intake is not significantly different. Muscle samples are collected from the same portion of the same muscle before and after the diet periods. Results which may contribute to the knowledge of obesity/lean-susceptibility are expected.

骨骼肌在能量代谢中起着重要作用。因此，它的特性已经在许多关于肥胖症和糖尿病的实验中进行了研究，以调查它们的贡献。根据主要来自横断面研究的临床和实验数据，认为肌肉中的纤维组成、毛细血管化、酶活性参与了肥胖的可能发病机制。然而，如果没有干预措施，所有这些横断面研究都不足以澄清任何这些假设。纵向研究为揭示骨骼肌特性与肥胖之间的因果关系提供了可能性。我们根据精确的研究方案进行了研究。在这些研究中，正在大鼠中研究骨骼肌对饮食诱导的体重控制的适应性。选择内脏脂肪作为分类标准。能量摄入没有显著差异。在饮食期之前和之后从相同肌肉的相同部分收集肌肉样品。预期结果可能有助于了解肥胖/瘦易感性。

项目成果

Zou B. et al.: "Adaptation in skeletal muscle characteristics to a high-fat diet in rats with different intra-abdominal-obesity susceptibilities"J Nutr Sci Vitaminol. accepted for publication.

Zou B. 等人：“具有不同腹内肥胖易感性的大鼠骨骼肌特征对高脂肪饮食的适应”J Nutr Sci Vitaminol。

Zou B.et al.: "Adaptation in skeletal muscle characteristics to a high-fat diet in rats with different intra-abdominal-obesity susceptibilities"J Nutr Sci Vitaminol. 49・4(accepted for publication). (2003)

Zou B.等人：“具有不同腹内肥胖易感性的大鼠骨骼肌特征对高脂肪饮食的适应”J Nutr Sci Vitaminol. 49·4（已接受出版）。

Zou B.et al.: "Overview of skeletal muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5・1. 1-13 (2003)

Zou B.et al.：“骨骼肌对饮食诱导体重控制的适应概述”Jpn J Health Prom Sci. 5・1（2003）。

Zou B. et al.: "Overview of muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5-1. 1-13 (2003)

Zou B.等人：“肌肉对饮食引起的体重控制的适应概述”Jpn J Health Prom Sci。

Zou B, Suwa M, Kumagai S: "Overview of skeletal muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5・1. 1-13 (2003)

Zou B，Suwa M，Kumagai S：“骨骼肌对饮食引起的体重控制的适应概述”Jpn J Health Prom Sci 5・1（2003）。