High-Resolution Spatiotemporal Brain Functional Imaging Using Equivalent Dipole Layer

使用等效偶极层的高分辨率时空脑功能成像

• 批准号: 13480291
• 负责人: HORI Junichi
• 金额: $ 8.51万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13480291/
• 关键词: brain imaging; dipole layer; projection filter spatiotemporal analysis; inverse problem; noise covariance; brain mapping; eye-blink artifact; 瞬目アーチファクト; パラメトリック射影フィルター; 時空問解析; 雑音の統計的情報

In the present study, we explore suitable spatio-temporal filters for inverse estimation of an equivalent dipole-layer distribution from the scalp EEG for imaging of brain electric sources. We propose a time-varying parametric projection filter (tPPF) for the spatio-temporal EEG analysis. Concretely, the regularization parameter and the noise covariance of the PPF were adjusted according to the signal and noise conditions. The performance of this tPPF algorithm was evaluated by computer simulation and human experimental studies. An inhomogeneous three-concentric-spheres model was used in the present simulation study to represent the head volume conductor. An equivalent dipole layer was used to represent equivalently brain electric sources and estimated from the scalp potentials. The tPPF filter was tested to remove time-varying noise such as instantaneous artifacts caused by eyes-blink. The present simulation results indicate that the proposed time-variant tPPF method provides enhanced performance in rejecting time-varying noise, as compared with the time-invariant parametric projection filter. Human experiments of visual evoked potential showed that the proposed method localized noise. Further investigations on other applications of this new method should be addressed in the future.

在本研究中，我们探索合适的时空滤波器的反向估计的等效偶极子层分布从头皮EEG脑电源成像。提出了一种时变参数投影滤波器（tpPF）用于脑电时空分析。具体地说，根据信号和噪声条件调整PPF的正则化参数和噪声协方差。该算法的性能进行了评估，通过计算机模拟和人体实验研究。一个非均匀的三个同心球模型在本模拟研究中使用的头部体积导体。等效偶极子层被用来等效地表示脑电源，并从头皮电位估计。测试了tPPF滤波器以去除时变噪声，例如由眨眼引起的瞬时伪影。目前的仿真结果表明，所提出的时变tPPF方法提供了增强的性能，在抑制时变噪声，与时不变的参数投影滤波器相比。视觉诱发电位的人体实验表明，该方法能够有效地定位噪声。这种新方法的其他应用的进一步调查应在未来解决。

项目成果

Hori, J., Lian, J., He, B.: "Cortical potential imaging of brain electrical activity by means of parametric projection filter"Proc. 4th Int. Workshop Biosignal Interpretation. 4. 311-314 (2002)

Hori，J.，Lian，J.，He，B.：“通过参数投影滤波器对脑电活动进行皮层电位成像”Proc。

Hori, J., Lian, J., He, B.: "Comparison between parametric Weiner filter and parametric projection filter in cortical equivalent dipole layer imaging"Proc. 2nd Joint EMBS/BMES Conf.. 2. 929-930 (2002)

Hori，J.，Lian，J.，He，B.：“皮质等效偶极层成像中参数化维纳滤波器与参数化投影滤波器的比较”Proc。

Hori, J.: "Spatio-temporal dipole source imaging of brain electrical activity by means of time-varying parametric projection filter"IEEE Trans.Biomed.Eng. 51・5. (2004)

Hori, J.：“通过时变参数投影滤波器对脑电活动进行时空偶极源成像”，IEEE Trans.Biomed.Eng（2004 年）。

Hori, J., Aiba, M., Saitoh, Y., He, B.: "Spatio-temporal brain electrical imaging based on time-varying spatial inverse filter"Proc.PIERS Progress in Electromagnetic Research Symposium. 518-518 (2003)

Hori, J.、Aiba, M.、Saitoh, Y.、He, B.：“基于时变空间逆滤波器的时空脑电成像”Proc.PIERS 电磁研究进展研讨会。

Hori, J., He, B.: "Equivalent dipole source imaging of brain electric activity by means of parametric projection filter"Annals of Biomedical Engineering. 29. 436-445 (2001)

Hori, J., He, B.：“通过参数投影滤波器对脑电活动进行等效偶极源成像”生物医学工程年鉴。