Diagnostic imaging for lung diseases using micro 3D CT image

使用微型 3D CT 图像诊断肺部疾病

• 批准号: 13480296
• 负责人: NIKI Noboru
• 金额: $ 6.46万
• 依托单位: University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13480296/
• 关键词: micro CT; lung disease; diagnostic imaging; pathology using X-ray; microstructure; 画像解析

We have developed a prototype system of micro CT scanner that is capable of imaging lung specimens with spatial resolution of 5 μ m. This prototype system allows us to precisely observe normal and abnormal microstructures of lung. Our purpose of this study is to establish a medical diagnostic technique based on micro CT images by building 3-D micro CT image database of lung diseases and by analyzing features of them.This study consists. of the following three parts : (1) measurement study of lung specimens, (2) visualization and numerical analysis of 3-D micro CT images, (3) performance improvement of the micro CT scanner system. Those parts are described below in detail.(1)It takes about twelve hours to measure a lung specimen in μ m order by the prototype system. One of difficulties of performing study is to keep stable situation of measurement system by controlling mechanical variations due to heat of the X-ray tube. The mechanical variations result in blurred images when reconstructing micro CT images. Through several measurement studies, we accumulated know-how to reconstruct lung specimens and collected 16 samples.(2)The development of visualization and analysis software tools is required to observe the lung specimens in μ m order. The visualization tools allow us to observe 3D lung specimen images interactively and to measure morphological features quantitatively. These sophisticated tools made it possible to investigate the structure analysis of lung cancers.(3)Reduction of the measurement time is one of problems to be solved for the micro CT imaging. For that we introduce a cone-beam measurement system with a flat panel detector into the micro CT scanner. The main difference between the latest prototype system and previous one is that an X-ray tube and a detector of the latest prototype rotate around a lung specimen.

我们研制了一台能够对肺标本进行空间分辨率为5μm的成像的微型CT扫描仪原型系统，该原型系统使我们能够精确地观察到肺的正常和异常的微结构。本研究的目的是通过建立肺部疾病的三维显微CT图像数据库，分析肺部疾病的特点，建立一种基于显微CT图像的医学诊断技术。包括以下三个部分：(1)肺标本的测量研究；(2)三维Micro CT图像的可视化与数值分析；(3)Micro CT扫描仪系统的性能改进。这些部分将在下面详细描述。(1)用原型系统测量一个μm量级的肺标本大约需要12个小时。研究的难点之一是通过控制X射线管热引起的力学变化来保持测量系统的稳定状态。在重建显微CT图像时，机械变化会导致图像模糊。通过多次测量研究，积累了肺标本的重建技术，采集了16例标本。(2)需要开发可视化分析软件工具对肺标本进行μm数量级的观察。可视化工具使我们能够交互地观察3D肺标本图像，并定量测量形态特征。这些复杂的工具使得研究肺癌的结构分析成为可能。(3)缩短测量时间是微型CT成像需要解决的问题之一。为此，我们在微型CT扫描仪中引入了带有平板探测器的锥束测量系统。最新的原型系统与以前的系统的主要区别在于，最新原型的X射线管和探测器绕着肺标本旋转。

项目成果

N.Niki et al.: "Image analysis of pulmonary nodules using micro CT"Proc. SPIE Medical Imaging. 4332. 718-725 (2001)

N.Niki 等人：“使用显微 CT 进行肺部结节的图像分析”Proc。

N.Niki, N.Moriyama: "Lung Cancer Diagnosis Using CAD"NICHIDOKU-IHO. Vol.48, No.1. 21-29 (2003)

N.Niki、N.Moriyama：“使用 CAD 进行肺癌诊断”NICHIDOKU-IHO。

N.Niki, Y.Kawata, E.Matsui, N.Moriyama: "Visualization of Lung Tissue Structure Using Micro CT"THE JOURNAL OF THE INSTITUTE ELECTRONICS INFORMATION AND COMMUNICATION ENGINEERS. Vol.85, No.10. 732-735 (2002)

N.Niki、Y.Kawata、E.Matsui、N.Moriyama：“使用显微 CT 实现肺组织结构的可视化”电子信息与通信工程师学会杂志。

仁木 登(分担執筆): "肺癌の最新医療"先端医療研究所. 7 (2003)

Noboru Niki（撰稿人）：《肺癌的最新医疗》《先进医学研究所》7（2003）。

Tetsuo Yamamoto: "Visualization and quantitative analysis of lung microstructure using micro CT images"Proceedings of SPIE Medical Imaging. (In press). (2004)

Tetsuo Yamamoto：“使用显微 CT 图像对肺微结构进行可视化和定量分析”SPIE 医学影像学报。