DEVELOPMENT OF ARITFICIAL VALVES FOR LUMINAL ORGANS

管腔器官人工瓣膜的开发

• 批准号: 13555058
• 负责人: TANAKA Mami
• 金额: $ 4.74万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13555058/
• 关键词: SHAPE MEMORY ALLOY; ARTIFICIAL URETHRAL VALVE; ARTIFICIAL RECTAL VALVE; TRANSCUTANEOUS ENERGY TRANSMISSION; THERMAL CONTROL; ANIMAL EXPERIMENT; LUMINAL ORGAN; 経皮的電力伝送装置

This study deals with the development of artificial valves used as sphincters for the luminal organs such as the urethras or the rectums. Aiming at the realization of durable, practical and easy-operating implanted artificial valves, materials, mechanical structure, motion characteristics, motion control, bio-compatibility and simplicity of clinical implantation of the valves are studied in this project.First, using a thin plate of the NiTi shape memory alloy (SMA) as the actuator, an artificial urethral valve for the treatment of incontinence of urine was developed. Transcutaneous energy transmission system providing energy to the implanted valve was also developed. Further effort was made in the improvements of the mechanical structure of the valve and the efficiency of the energy transmission. A closed loop thermal control system was developed and integrated into the energy transmission system in order to prevent over-heating of the SMA surface. Through animal experiments using dogs … More , the efficiency of the whole system as an artificial urethral sphincter was verified.Based on the experience and achieved results so far, in the last fiscal year of the project, effort was made in expending the application of the valve to the treatment of incontinence of feces. A rectal valve was developed. Structure of the valve was redesigned to meet the need of the rectal valve. Higher efficiency of transcutaneous energy transmission was obtained through further improvement of the transmission system. More reliable information transmission circuit was developed to obtain a more stable thermal control of the SMA actuator of the valve. Finally, the rectal valve, transcutaneous energy transmission system, and the thermal control system were tested by animal experiments using dogs. Experiment results verified the usefulness of the developed valve system as an artificial rectal sphincter.In conclusion, an artificial urethral valve system and an artificial rectal valve system using SMA as actuators are developed. Efficacy of their function as artificial valves used as sphincters for the luminal organs is testified. Less

本研究涉及人工瓣膜的发展，用作尿道或直肠等内脏器官的括约肌。本课题以实现耐用、实用、易操作的植入人工瓣膜为目标，对瓣膜的材料、机械结构、运动特性、运动控制、生物相容性和临床植入简洁性进行了研究。首先，以NiTi形状记忆合金（SMA）的薄片为致动器，研制了一种治疗尿失禁的人工尿道阀。经皮能量传输系统为植入的瓣膜提供能量。进一步改进了阀门的机械结构，提高了能量传递的效率。为了防止SMA表面过热，开发了闭环热控制系统，并将其集成到能量传输系统中。通过狗的动物实验，验证了整个系统作为人工尿道括约肌的有效性。根据迄今取得的经验和成果，在项目的最后一个财政年度，努力扩大该阀在治疗大便失禁方面的应用。研制了直肠瓣膜。重新设计了阀的结构，以满足直肠阀的需要。通过对传输系统的进一步改进，获得了更高的经皮能量传输效率。开发了更可靠的信息传输电路，实现了对阀门SMA执行器更稳定的热控制。最后采用犬类动物实验对直肠阀、经皮能量传递系统、热控系统进行测试。实验结果验证了所开发的瓣膜系统作为人工直肠括约肌的有效性。综上所述，我们开发了一种以SMA为执行器的人工尿道阀系统和人工直肠阀系统。它们作为人造瓣膜用作管腔器官的括约肌的功效得到证实。少

项目成果

Mami Tanaka, et al.: "Artificial urethral valve driven by SMA actuators with transcutaneous energy transmission system"International Journal of Applied Electromagnetics and Mechanics. 18(1-3). 23-30 (2003)

Mami Tanaka 等人：“具有经皮能量传输系统的 SMA 执行器驱动的人工尿道瓣膜”国际应用电磁学和力学杂志。

Mami Tanaka, Takashige Namima, Seiji Chonan, 他2名: "Development of mechanical SMA urethral valve with transcutaneous energy transformer"JSAEM Studies in Applied Electromagnetics and Mechanics. 9. 421-422 (2001)

Mami Tanaka、Takashige Namima、Seiji Chonan 等 2 人：“带有经皮能量转换器的机械 SMA 尿道瓣膜的开发”JSAEM 应用电磁学和力学研究 9. 421-422 (2001)。

M.Tanaka, et al.: "A Closed Loop Transcutaneous Power Transmission System with Thermal Control for Artificial Urethral Valve Driven by SMA Actuator"Proceedings of International Symposium on Smart Materials for Engineering and Biomedical Applications. (印刷中

M. Tanaka 等人：“由 SMA 执行器驱动的人工尿道瓣膜具有热控制的闭环经皮动力传输系统”工程和生物医学应用智能材料国际研讨会论文集（正在出版）

田中真美(執筆分担): "マイクロマシン技術総覧"(株)産業技術サービスセンター. 750 (2002)

田中麻美（合着）：《微型机械技术概要》工业技术服务中心株式会社750（2002年）

Mami Tanaka, Feng Wang, Kazuhiro Abe, Yoichi Arai, Haruo Nakagawa, Seiji Chonan: "A Closed Loop Transcutaneous Energy Transmission System for an SMA-actuated Artificial Urethral Valve"Proc. of the International Conference on Mechatronics and Information T

Mami Tanaka、Feng Wang、Kazuhiro Abe、Yoichi Arai、Haruo Nakakawa、Seiji Chonan：“用于 SMA 驱动人工尿道瓣膜的闭环经皮能量传输系统”Proc。