Damage Analysis by Elongation of Blood Vessels

通过血管伸长进行损伤分析

• 批准号: 13557035
• 负责人: FUNAYAMA Masato
• 金额: $ 3.14万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557035/
• 关键词: injury of vessels; disruption of vessels; elongation of vessels; aorta; trauma; stress; strain; 血管変性; 加速度; 動物実験; 動脈; 張力; 変位量

The device was designed to analyze the damages to blood vessels while elongating beyond its physiological limits. It consists of a stepping motor, pulse generator, leaf spring and data transmission. Elongating speed is controlled by either constant or accelerated. A non-traumatic grasping forceps was used to fix at each end of a vessel. For purpose of data collections of uniform samples, rectangular materials (10 x 4 mm) of aorta of rabbits were trimmed with the longitudinal or horizontal direction of it, and set and pulled. Strain-stress curves during vessel elongations showed a certain pattern even though they appeared to have a large degree of dispersions. The values of stress increased slowly after starting elongation (the first stage), and then increases of stress raised sharply (the second stage). After reaching a peak, the values of stress decreased (the third stage). The first stage would show the normal physiological phase of extension and shrinkage that normal vessels have, and the second stage would show own characteristics of each vessel. And the third stage was destructive one. After improper materials were eliminated, the values of stress and strain were statistically compared between materials of longitudinal and horizontal direction. The similar tendency was obtained from a fixed speed (40mm/mm) and an acceleration (0.000467m/s^2). In this study, we established how to analyze disruption of the ^*large-sized arteries while elongating, however, in case of the median-sized arteries like vertebral arteries, further improvement of the grasping pars is needed.

该装置被设计用于分析在伸长超过其生理极限时对血管的损伤。它由步进电机、脉冲发生器、片簧和数据传输部分组成。拉伸速度由恒定或加速控制。使用非创伤性抓钳固定血管两端。为了收集均匀样品的数据，将兔主动脉的矩形材料（10 x 4 mm）沿其纵向或水平方向修剪，并固定和牵拉。在血管伸长过程中的应变-应力曲线显示出一定的模式，即使他们似乎有很大程度的分散。开始拉伸后应力值缓慢增加（第一阶段），随后应力值急剧增加（第二阶段）。达到峰值后，应力值下降（第三阶段）。第一个阶段将显示正常血管的正常生理伸展和收缩阶段，第二个阶段将显示每个血管的自身特征。第三个阶段是毁灭性的。剔除不合适材料后，对纵向和横向材料的应力和应变值进行统计比较。在固定速度（40 mm/mm）和加速度（0.000467 m/s^2）下，也得到了类似的趋势。在本研究中，我们确定了如何分析伸长时大动脉的断裂，然而，对于中等动脉（如椎动脉），需要进一步改进抓握部分。

项目成果

Y Yajima, M Nata, M Funayama et al.: "Intracerebral haematoma : traumatic or non-traumatic"J Clin Forensic Med. 8. 163-165 (2001)

Y Yajima、M Nata、M Funayama 等人：“脑内血肿：创伤性或非创伤性”J Clin Forensic Med。

矢嶋幸仁, 舟山眞人, 小山清人, 那谷雅之他: "血管特性ならびに損傷解析を目的とした血管変性装置の開発(抄録)"日本法医学雑誌. 51(1). 99 (2003)

Yukihito Yajima、Masato Funayama、Kiyoto Koyama、Masayuki Natani 等人：“用于血管特征和损伤分析的血管变性装置的开发（摘要）”日本法医学杂志 51(1) 99 (2003)。

Y Yajima et al.: "Intracerebral haematoma : traumatic or non-traumatic"J Clin Forensic Med. 8. 163-165 (2001)

Y Yajima 等人：“脑内血肿：创伤性或非创伤性”J Clin Forensic Med。

境 純, 舟山眞人, 那谷雅之他: "後頭蓋窩血腫が死因に関与していると考えられた1例"法医学の実際と研究. 46. 85-89 (2003)

Jun Sakai、Masato Funayama、Masayuki Natani 等：“后颅窝血肿被认为与死亡原因有关的案例”《法医学实践与研究》46. 85-89 (2003)。

Y Yajima et al.: "Intracerebral haematoma : traumatic or non-traumatic. Authors response (letter)"J Clin Forensic Med. 9. 199-200 (2002)

Y Yajima 等人：“脑内血肿：创伤性或非创伤性。作者回应（信件）”J Clin Forensic Med。